Precision mechanics with multifunctional tools: how hnRNP K and hnRNPs E1/E2 contribute to post-transcriptional control of gene expression in hematopoiesis.
Precision mechanics with multifunctional tools: how hnRNP K and hnRNPs E1/E2 contribute to post-transcriptional control of gene expression in hematopoiesis.
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DOI：
10.2174/138920312801619484
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发表时间：
2012-05
影响因子：
2.8
通讯作者：
A. Ostareck-Lederer;D. Ostareck
中科院分区：
文献类型：
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作者：
A. Ostareck-Lederer;D. Ostareck
对造血细胞基因表达转录后调控的研究发现，异质核核糖核蛋白（hnRNPs）亚家族参与细胞质基因调控。其中hnRNP K和hnRNPs E1/E2具有共同的结构基序，hnRNP K同源（KH）结构域为RNA结合提供了功能基础。特异性亚细胞定位和分化依赖的翻译后修饰调节这些蛋白质与mRNA和信使核糖核蛋白复合物（mRNPs）中的蛋白质的相互作用，后者产生与细胞信号转导事件的连接。hnRNP K和hnRNPs E1/E2作为不同mRNPs的组成部分，在造血细胞分化过程中作为mRNA稳定性和翻译的重要调节因子。
Studies on the post-transcriptional control of gene expression in hematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. Among them hnRNP K and hnRNPs E1/E2 share common structural motifs, the hnRNP K homology (KH) domains that provide a functional basis for RNA binding. Specific sub-cellular localization and differentiation dependent post-translational modifications modulate the interaction of these proteins with mRNA and proteins in messenger ribonucleoprotein complexes (mRNPs), the latter generating connectivity to cell signaling events. As components of different mRNPs, hnRNP K and hnRNPs E1/E2 function as crucial modulators of mRNA stability and translation in hematopoietic cell differentiation.