Vitreous Levels of VEGF, IL-8, and TNF-α in Retinal Detachment
Vitreous Levels of VEGF, IL-8, and TNF-α in Retinal Detachment
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DOI：
10.3109/02713681003597248
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发表时间：
2010-06-01
影响因子：
2
通讯作者：
Bahcecioglu, Halil
中科院分区：
文献类型：
--
作者：
Rasier, Rifat;Gormus, Uzay;Bahcecioglu, Halil
目的：目的：检测孔源性视网膜脱离（RD）患者玻璃体内白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）和血管内皮生长因子（VEGF）的水平。对于对照组，玻璃体样本从12例患者的12只眼睛没有RD在睫状体平坦部玻璃体切除术。对照组患者包括4例黄斑裂孔和8例视网膜前膜;没有任何相关的玻璃体视网膜病变。结果：与对照组患者的样本相比，RD患者的样本中VEGF浓度显著升高（p < 0.001）。当与对照患者相比时，黄斑水肿患者中IL-8的维生素浓度也显著升高（p < 0.05）。结论：IL-8（一种炎性血管生成介质）和VEGF（一种细胞增殖和通透性调节介质）的升高可能与增生性玻璃体视网膜病变的发生有关。
Purpose: To determine intravitreal levels of interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), and vascular endothelial growth factor (VEGF) in patients with rhegmatogenous retinal detachment (RD).Methods: Vitreous samples were collected from 22 eyes of 22 patients during vitrectomy procedures for RD. For controls, vitreous samples were obtained from 12 eyes of 12 patients without RDs during pars plana vitrectomies. Control group patients included four with macular holes and eight with epiretinal membranes; none had any associated vitreoretinopathy. All vitreous samples were immediately frozen at -80 degrees C until assayed.Results: VEGF concentrations were significantly elevated in samples from patients with RDs compared to samples from control patients (p < 0.001). Vitreous concentrations of IL-8 were also significantly elevated in patients with macular edema when compared to control patients (p < 0.05). However, no significant difference was observed in vitreous concentrations of TNF-alpha in subjects with RDs compared to control subjects (p > 0.05).Conclusions: Increases in IL-8 (an inflammatory angiogenic mediator) and VEGF (a regulatory mediator of cellular proliferation and permeability) may be related to development of proliferative vitreoretinopathy.