Adiponectin gene single-nucleotide polymorphisms and treatment response to obesity
Adiponectin gene single-nucleotide polymorphisms and treatment response to obesity
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DOI：
10.1007/bf03346474
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发表时间：
2009-05-01
影响因子：
5.4
通讯作者：
Sakane, N.
中科院分区：
文献类型：
--
作者：
Tsuzaki, K.;Kotani, K.;Sakane, N.
背景：在脂联素基因的多态中，单核苷酸多态(SNP)-45和SNP276已被报道与肥胖、2型糖尿病等代谢综合征相关。目的：在肥胖受试者的热量限制中，这些脂联素SNP是否影响肥胖相关参数。对象和方法：32名日本肥胖女性接受了8周的低卡路里饮食替代餐治疗，并被要求保持其习惯性生活方式。观察治疗前后肥胖相关指标的变化。我们利用荧光等位基因特异的DNA引物检测系统和FRET探针检测系统检测了4个SNP(T45G、I164T、G276T和C-11377G)。结果：治疗后，携带G/G或G/T基因型者腰围下降幅度大于携带T/T基因型者(P=0.026)。对于SNP45，TIT基因携带者甘油三酯水平的下降幅度大于T/G基因携带者(P=0.003)。对于SNP-11377，携带C/G或G/G基因型者的收缩压和空腹血糖的下降幅度大于携带C/C基因型者(p=0.044)。结论：我们的研究结果表明，脂联素基因中的每个SNP可能改变了低热量饮食替代膳食过程中肥胖相关参数的变化。(J.内分泌。投资。32：395-400,2009)(C)2009，编辑：库尔蒂斯
Background: In the adiponectin gene polymorphisms, single-nucleotide polymorphism (SNP)-45 and SNP276 have reportedly been associated with obesity, Type 2 diabetes, and other features of metabolic syndrome. Aim: Whether these adiponectin SNP affect obesity-related parameters during caloric restriction in obese subjects. Subjects and methods: Thirty-two obese Japanese women were treated by meal replacement with a low calorie diet for 8 weeks and asked to maintain their habitual lifestyle. Obesity-related parameters were measured before and after the treatment period. We determined four SNP (T45G, I164T, G276T, and C-11377G) using a fluorescent allele-specific DNA primer assay system and FRET probe assay system. Results: After the treatment, the extent of decrease in waist circumference was greater in the subjects with the G/G or G/T genotype of SNP276 than in those with the T/T genotype (p=0.026). As for SNP45, the extent of decrease in triglyceride levels was greater in the subjects with the TIT genotype than in those with the T/G genotype (p=0.003). For SNP-11377, the extent of decrease in systolic blood pressure and fasting plasma glucose was greater in the subjects with the C/G or G/G genotype than in those with the C/C genotype (p=0.044). Conclusion: Our findings indicate that each SNP in the adiponectin gene might modify the change in obesity-related parameters during meal replacement with a low calorie diet. (J. Endocrinol. Invest. 32: 395-400, 2009) (C) 2009, Editrice Kurtis