The stem cell-specific intermediate filament nestin missense variation p.A1199P is associated with pancreatic cancer
The stem cell-specific intermediate filament nestin missense variation p.A1199P is associated with pancreatic cancer
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DOI：
10.3892/ol.2019.10106
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发表时间：
2019-05-01
期刊：
影响因子：
2.9
通讯作者：
Arai, Tomio
中科院分区：
文献类型：
--
作者：
Matsuda, Yoko;Tanaka, Masashi;Arai, Tomio
中间丝巢蛋白在干/祖细胞和癌症中上调，并调节细胞增殖、迁移、侵袭和干性。本研究比较分析了日本患者（n=2,206;男性，1,225;女性，981;中位数，80.7岁;范围，33-104岁）与整个器官的恶性肿瘤的系列尸检，就临床信息，和巢蛋白基因的5个单核苷酸多态性。p.A1199P与胰腺癌相关（比值比，4.4; 95%置信区间，1.9-10.0，P=0.001），而与其他器官的恶性肿瘤无关。p.A1199P与胰腺癌前病变无关。巢蛋白单核苷酸多态性与性别、饮酒、吸烟或体重无关。总之，巢蛋白的氨基酸1，199定位于丝状体的尾部结构中，并与其他中间丝状体蛋白聚合。目前的研究结果表明，错义巢蛋白的变化影响胰腺癌在日本患者。
The intermediate filament nestin is upregulated in stem/progenitor cells and cancers, and regulates cell proliferation, migration, invasion and stemness. The present study comparatively analyzed serial autopsies of Japanese patients (n=2,206; males, 1,225; females, 981; median, 80.7 years old; range, 33-104 years old) with malignant tumors of whole organs, with respect to the clinical information, and 5 single nucleotide polymorphisms of the nestin gene. p.A1199P associated with pancreatic cancer (odds ratio, 4.4; 95% confidence interval, 1.9-10.0, P=0.001) while it did not associate with malignant neoplasms in other organs. p.A1199P did not associate with precancerous lesions of the pancreas. Single nucleotide polymorphisms of nestin were not associated with sex, drinking, smoking, or body weight. In conclusion, the amino acid 1,199 of nestin is localized in the tail structure of the filament and polymerizes with other intermediate filament proteins. The present results suggest that missense variations of nestin affect pancreatic carcinogenesis in Japanese patients.