Role of Steroids in the Management of Diabetic Macular Edema and Proliferative Diabetic Retinopathy
Role of Steroids in the Management of Diabetic Macular Edema and Proliferative Diabetic Retinopathy
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DOI：
10.1080/08820530902800355
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发表时间：
2009-01-01
影响因子：
1.7
通讯作者：
Aiello, Lloyd Paul
中科院分区：
文献类型：
--
作者：
Silva, Paolo S.;Sun, Jennifer K.;Aiello, Lloyd Paul
糖尿病视网膜病变是糖尿病最常见的微血管并发症。早期临床试验已证实激光治疗增殖性糖尿病视网膜病变(PDR)和糖尿病黄斑水肿(DME)的有效性和安全性。尽管及时和适当地使用激光，一些患者仍继续经历视力丧失。PDR和DME的发病机制是多因素的，既涉及血管生成过程，也涉及炎症过程。最近的试验表明，皮质类固醇的抗炎和抗血管生成特性可能在治疗PDR和DME方面有好处。类固醇在治疗糖尿病视网膜病变和黄斑水肿中的确切作用仍有待充分阐明。
Diabetic retinopathy is the most common microvascular complication of diabetes. Early clinical trials have established the efficacy and safety of laser in the treatment of proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME). Despite timely and appropriate use of laser, some patients continue to experience visual loss. The pathogenesis of PDR and DME is multifactorial involving both angiogenic and inflammatory processes. Recent trials have shown that the anti-inflammatory and anti-angiogenic properties of corticosteroids may provide benefit in treating PDR and DME. The exact role of steroids in the treatment for diabetic retinopathy and macular edema remains to be fully elucidated.