Acute hemodynamic effects of nitroglycerin in pulmonary hypertension.
Acute hemodynamic effects of nitroglycerin in pulmonary hypertension.
复制标题
硝酸甘油对肺动脉高压的急性血流动力学影响。
DOI：
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发表时间：
1983
影响因子：
39.2
通讯作者：
J. Ashton
中科院分区：
文献类型：
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作者：
R. Pearl;M. Rosenthal;J. Schroeder;J. Ashton
肺动脉高压的治疗受到当前肺血管扩张剂的低效力和副作用的限制。硝酸甘油对人肺动脉高压的血流动力学影响尚不清楚。我们给9名慢性肺动脉高压患者服用硝酸甘油。硝酸甘油使心脏指数增加40%（p小于0.01），每搏输出量增加40%（p小于0.01），肺血管阻力降低40%（p小于0.01），平均肺动脉压降低15%（p小于0.01）。9名患者中有8名患者的肺血管阻力下降超过25%。在4例患者中，局部硝酸甘油制剂再现了静脉注射硝酸甘油的效果;心脏指数增加50%，每搏输出量增加48%，肺血管阻力降低43%，平均肺动脉压降低19%。六名接受长效硝酸盐治疗的患者中有五名症状有实质性改善。我们的结论是硝酸甘油治疗重度肺动脉高压患者是有效的。
Therapy of pulmonary hypertension is limited by the low potency and adverse effects of current pulmonary vasodilators. The hemodynamic effects of nitroglycerin in human pulmonary hypertension are not known. We administered nitroglycerin to nine patients with chronic pulmonary hypertension. Nitroglycerin increased cardiac index 40% (p less than 0.01), increased stroke volume 40% (p less than 0.01), decreased pulmonary vascular resistance 40% (p less than 0.01), and decreased mean pulmonary artery pressure 15% (p less than 0.01). Pulmonary vascular resistance decreased more than 25% in eight of the nine patients. In four patients the effects of intravenous nitroglycerin were reproduced by topical nitroglycerin preparations; cardiac index increased 50%, stroke volume increased 48%, pulmonary vascular resistance decreased 43%, and mean pulmonary artery pressure decreased 19%. Five of six patients treated with long-acting nitrates had substantial improvement of their symptoms. We conclude that therapy with nitroglycerin can be effective in patients with severe pulmonary hypertension.