Two new sesquiterpene aryl esters from Armillaria gallica 012m.
Two new sesquiterpene aryl esters from Armillaria gallica 012m.
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来自高卢蜜环菌 012m 的两种新倍半萜芳基酯。
DOI：
10.1080/10286020.2021.1878156
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发表时间：
2021
影响因子：
1.7
通讯作者：
Wang Wei-Guang
中科院分区：
文献类型：
--
作者：
Lou Shui-Zhu;Feng Jian;Yang Run;Li Yan-Ping;Gao Lu;Du Gang;Yang Hai-Ying;Hu Qiu-Fen;Zhou Wen-Bing;Wang Li-Sheng;Wang Wei-Guang
通过硅胶柱层析、反相C18硅胶柱层析和半制备型高效液相色谱，从蜜环菌012 m的乙酸乙酯提取物中分离得到两个新的倍半萜芳基酯化合物：armimelleolides A和B（1和2），以及四个已知化合物。化合物的结构经1DNMR、2DNMR和MS等波谱方法确证。所有化合物对人癌细胞株（A549、HCT-116、M231和W256）均具有潜在的抗肿瘤活性，IC 50为2.57 ~ 19.94 μM。
Two new sesquiterpene aryl esters, armimelleolides A and B (1and2), and four known ones, were isolated from the EtOAc extract ofArmillaria gallica012 m by column chromatography on silica gel, reversed-phase C18silica gel and semi-preparative HPLC. Their structures were elucidated on the basis of spectroscopic methods, including extensive 1 D NMR, 2 D NMR and MS. All these compounds showed potential antitumor activities against at least one of the human cancer cell lines (A549, HCT-116, M231 and W256), with IC50ranging from 2.57 to 19.94 μM.