Cellular magnetic resonance imaging: potential for use in assessing aspects of cardiovascular disease.
Cellular magnetic resonance imaging: potential for use in assessing aspects of cardiovascular disease.
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DOI：
10.1080/14653240802165699
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发表时间：
2008
期刊：
影响因子：
4.5
通讯作者：
Zhuoli Zhang;N. Mascheri;R. Dharmakumar;Debiao Li
中科院分区：
文献类型：
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作者：
Zhuoli Zhang;N. Mascheri;R. Dharmakumar;Debiao Li
利用磁共振成像(MRI)来跟踪细胞在体内的迁移，引起了人们越来越多的兴趣。氧化铁磁共振造影剂可以检测到微摩尔浓度的铁，并为T2*加权成像提供足够的灵敏度。细胞核磁共振显示出评估心血管疾病的潜力。利用纳米氧化铁在体内标记和追踪巨噬细胞一直是细胞磁共振的目标，因为巨噬细胞在包括动脉粥样硬化在内的许多人类疾病的病理生理学中发挥着关键作用。细胞核磁共振也被用来追踪移植的治疗细胞在心肌再生过程中的情况。本文综述了氧化铁纳米颗粒、细胞标记方法、图像获取技术以及在可视化方面遇到的限制。特别关注心血管系统的干细胞和巨噬细胞。
There is rapidly increasing interest in the use of magnetic resonance imaging (MRI) to track cell migration in vivo. Iron oxide MR contrast agents can be detected at micromolar concentrations of iron, and offer sufficient sensitivity for T2*-weighted imaging. Cellular MRI shows potential for assessing aspects of cardiovascular disease. Labeling in vivo and tracking macrophages using iron oxide nanoparticles has been a goal for cellular MRI because macrophages play a pivotal role in the pathophysiology of many human diseases, including atherosclerosis. Cellular MRI has also been using to track transplanted therapeutic cells in myocardial regeneration. This review looked at iron oxide nanoparticles, methods of cell labeling, image acquisition techniques and limitations encountered for visualization. Particular attention was paid to stem cells and macrophages for the cardiovascular system.