Atmospheric-pressure plasma-jet from micronozzle array and its biological effects on living cells for cancer therapy
Atmospheric-pressure plasma-jet from micronozzle array and its biological effects on living cells for cancer therapy
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DOI：
10.1063/1.3555434
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发表时间：
2011-02-14
影响因子：
4
通讯作者：
Yang, Sang Sik
中科院分区：
文献类型：
--
作者：
Kim, Kangil;Choi, Jae Duk;Yang, Sang Sik
我们提出了一种等离子体射流装置与微米大小的喷嘴阵列用于癌症治疗。此外，我们还展示了大气压等离子体对活细胞的生物学效应。氮等离子体激活了一种替代DNA损伤信号转导途径，称为共济失调毛细血管扩张突变（ATM）-检查点激酶2途径，表明氮等离子体产生DNA双链断裂。在等离子体处理的细胞中检测到H2 AX和p53的磷酸化，导致凋亡性细胞死亡。因此，氮等离子体在控制凋亡性细胞死亡中的作用提供了对氮等离子体的生物学作用如何应用于控制细胞存活的洞察，这是具有潜在治疗意义的发现。(C)2011年美国物理学会。[doi：10.1063/1.3555434]
We propose a plasma-jet device with a micrometer-sized nozzle array for use in a cancer therapy. Also, we show the biological effects of atmospheric-pressure plasma on living cells. Nitrogen-plasma activated a surrogate DNA damage signal transduction pathway, called the ataxia telangiectasia mutated (ATM)-checkpoint kinase 2 pathway, suggesting that the nitrogen-plasma generates DNA double-strand breaks. Phosphorylation of H2AX and p53 was detected in the plasma-treated cells, leading to apoptotic cell death. Thus, an effect for the nitrogen plasma in the control of apoptotic cell death provides insight into the how biological effects of the nitrogen-plasma can be applied to the control of cell survival, a finding with potential therapeutic implications. (C) 2011 American Institute of Physics. [doi:10.1063/1.3555434]