Systemic differences in serum metabolome: a cross sectional comparison of women with localised and widespread pain and controls.
Systemic differences in serum metabolome: a cross sectional comparison of women with localised and widespread pain and controls.
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DOI：
10.1038/srep15925
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发表时间：
2015-11-02
影响因子：
4.6
通讯作者：
Hellström F
中科院分区：
文献类型：
--
作者：
Hadrévi J;Björklund M;Kosek E;Hällgren S;Antti H;Fahlström M;Hellström F
慢性肌肉骨骼疼痛要么局限于单个区域，要么广泛分布于身体多个象限的多个部位。前瞻性研究表明，广泛的疼痛可能是始于慢性局部疼痛的肌肉骨骼疼痛连续体的远端。尽管许多研究表明这是新陈代谢的改变，但从局部疼痛转变为广泛疼痛的机制尚不清楚。在这项研究中，评估了患有慢性局部颈肩痛 (NP) 的女性、患有慢性广泛性疼痛 (CWP) 的女性和健康女性 (CON) 之间的全身代谢差异。使用气相色谱质谱法 (GC-MS) 和正交偏最小二乘判别分析 (OPLS-DA) 采用代谢组学方法对血液样本进行分析。代谢组学分析显示，NP 和 CON 受试者之间的代谢谱存在明显的系统性差异，但 CWP 和 CON 受试者之间只有微弱的系统性差异。这很可能反映了受两种疼痛状况影响的代谢组部分的差异。在 NP 组中，总体代谢特征表明，与能量利用和脂质代谢相关的过程可能是维持紊乱机制的核心方面。
Chronic musculoskeletal pain exists either as localised to a single region or as widespread to multiple sites in several quadrants of the body. Prospective studies indicate that widespread pain could act as a far end of a continuum of musculoskeletal pain that started with chronic localised pain. The mechanism by which the transition from localised pain to widespread occurs is not clear, although many studies suggest it to be an altered metabolism. In this study, systemic metabolic differences between women with chronic localised neck-shoulder pain (NP), women with chronic widespread pain (CWP) and women who were healthy (CON) were assessed. Blood samples were analysed taking a metabolomics approach using gas chromatography mass spectrometry (GC-MS) and orthogonal partial least square discriminant analysis (OPLS-DA). The metabolomics analysis showed a clear systematic difference in the metabolic profiles between the subjects with NP and the CON but only a weak systematic difference between the subjects with CWP and the CON. This most likely reflects a difference in the portion of the metabolome influenced by the two pain conditions. In the NP group, the overall metabolic profile suggests that processes related to energy utilisation and lipid metabolism could be central aspects of mechanisms maintaining disorder.