Defect-Mediated Morphologies in Growing Cell Colonies
Defect-Mediated Morphologies in Growing Cell Colonies
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DOI：
10.1103/physrevlett.117.048102
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发表时间：
2016-07-20
影响因子：
8.6
通讯作者：
Yeomans, Julia M.
中科院分区：
文献类型：
--
作者：
Doostmohammadi, Amin;Thampi, Sumesh P.;Yeomans, Julia M.
活细胞集落生长的形态趋势是生理和进化过程的核心。使用活性凝胶方程，其中包括细胞分裂，我们表明，在生长过程中的形状变化可以调节的细胞取向的拓扑缺陷的动力学。分裂细胞和底层基质之间的摩擦通过介导拓扑缺陷的数量密度和速度，驱动各向异性的菌落形状朝向更各向同性的形态。我们发现，缺陷与界面在一个特定的相互作用范围内，设置由涡度长度尺度内的流量殖民地，和细胞主要重新定向平行于界面，由于分裂引起的主动应力。
Morphological trends in growing colonies of living cells are at the core of physiological and evolutionary processes. Using active gel equations, which include cell division, we show that shape changes during the growth can be regulated by the dynamics of topological defects in the orientation of cells. The friction between the dividing cells and underlying substrate drives anisotropic colony shapes toward more isotropic morphologies, by mediating the number density and velocity of topological defects. We show that the defects interact with the interface at a specific interaction range, set by the vorticity length scale of flows within the colony, and that the cells predominantly reorient parallel to the interface due to division-induced active stresses.