The origins of age-related proinflammatory state
The origins of age-related proinflammatory state
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DOI：
10.1182/blood-2004-07-2599
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发表时间：
2005-03-15
期刊：
影响因子：
20.3
通讯作者：
Longo, DL
中科院分区：
文献类型：
--
作者：
Ferrucci, L;Corsi, A;Longo, DL
我们假设，随着年龄的增长，炎症标志物水平的上升是由心血管危险因素和发病率在老年人中逐渐变得更加普遍来解释的。从一般人群(年龄20-102岁)中抽取了595名男性和748名女性，收集了有关炎症标志物、心血管危险因素和疾病的信息。在男性和女性中，年龄越大，白介素6(IL-6)、IL-1受体拮抗剂(IL-1ra)、IL-18、C反应蛋白(CRIP)和纤维蛋白原水平越高，而可溶性IL-6受体(sIL-6R)仅在男性随年龄增加而显著增加。校正心血管危险因素和发病率后，在预测IL-6、IL-1ra、IL-18和纤维蛋白原的模型中，年龄回归系数显著变小，而在预测sIL6r的模型中，年龄回归系数变大。对心血管发病率进行调整后，男性的年龄对C反应蛋白的影响显著降低，但女性的影响不大。这一发现在51名男性和45名女性中得到了证实，他们的风险水平较低，没有心血管疾病。老年人的“促炎状态”部分与心血管危险因素的高患病率和发病率有关。(C)2005年，由美国血液病学会提供。
We hypothesized that the rising levels of inflammatory markers, with aging is explained by cardiovascular risk factors and morbidity becoming progressively more prevalent in older persons. information on inflammatory markers, cardiovascular risk factors, and diseases was collected in 595 men and 748 women sampled from the general population (age, 20-102 years). In both men and women, older age was associated with higher levels of interleukin-6 (IL-6), IL-1 receptor antagonist (IL-1ra), IL-18, C-reactive protein (CRIP), and fibrinogen, while soluble IL-6 receptor (sIL-6r) increased significantly with age only in men. Adjusting for cardiovascular risk factors and morbidity, the age regression coefficients became substantially smaller in models predicting IL-6, IL-1ra, IL-18, and fibrinogen and larger in the model predicting sIL6r. Adjustment for cardiovascular morbidity substantially reduced the effect of age on CRP in men but not in women. Findings were confirmed in a subgroup of 51 men and 45 women with low risk profile and no cardiovascular morbidity. Part of the "proinflammatory state" in older persons is related to the high prevalence of cardiovascular risk factor and morbidity. (c) 2005 by The American Society of Hematology.