Rhesus monkeys with orbital prefrontal cortex lesions can learn to inhibit prepotent responses in the reversed reward contingency task
Rhesus monkeys with orbital prefrontal cortex lesions can learn to inhibit prepotent responses in the reversed reward contingency task
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DOI：
10.1093/cercor/bhl025
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发表时间：
2007-05-01
期刊：
影响因子：
3.7
通讯作者：
Murray, E. A.
中科院分区：
文献类型：
--
作者：
Chudasama, Y.;Kralik, J. D.;Murray, E. A.
患有眶前额叶皮层（PFo）损伤的猴子在行为任务中受损，这些任务需要灵活应对奖励偶然性变化的能力（例如，对象反转学习和灭绝）。在啮齿动物和人类中的这些和相关发现表明，PFo对于克服优势反应所需的抑制控制至关重要。为了验证这一想法，我们训练了PFo病变的恒河猴和未操作的控制收购的反向奖励应急任务。在这个任务中，选择两个食物量中较小的一个（1个半花生[1P]）会导致收到较大的一个（4个半花生[4P]），反之亦然。选择大量的食物是一种可靠的优生反应，因此，所有的猴子最初选择4P而不是一个。然而，随着经验的积累，所有的猴子都学会了选择1P来获得4。令人惊讶的是，有PFo病变的猴子和未手术的对照组学习得一样快。因此，PFo病变不会在所有需要抑制优势反应的试验中产生缺陷。
Monkeys with lesions of the orbital prefrontal cortex (PFo) are impaired on behavioral tasks that require the ability to respond flexibly to changes in reward contingency (e.g., object reversal learning and extinction). These and related findings in rodents and humans have led to the suggestion that PFo is critical for the inhibitory control needed to overcome prepotent responses. To test this idea, we trained rhesus monkeys with PFo lesions and unoperated controls on acquisition of the reversed reward contingency task. In this task, selecting the smaller of 2 food quantities (1 half peanut [1P]) leads to receipt of the larger quantity (4 half peanuts [4P]) and vice versa. Choice of a larger quantity of food is a reliable prepotent response, and, accordingly, all monkeys initially selected 4P rather than one. With experience, however, all monkeys learned to select 1P in order to receive 4. Surprisingly, monkeys with PFo lesions learned as quickly as unoperated controls. Thus, PFo lesions do not yield a deficit in all tests that require the inhibition of a prepotent response.