Graph analysis of cortical networks reveals complex anatomical communication substrate
Graph analysis of cortical networks reveals complex anatomical communication substrate
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DOI：
10.1063/1.3089559
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发表时间：
2009-03-01
期刊：
影响因子：
2.9
通讯作者：
Kurths, Juergen
中科院分区：
文献类型：
--
作者：
Zamora-Lopez, Gorka;Zhou, Changsong;Kurths, Juergen
进入神经系统的感觉信息遵循独立的处理路径，以便单独检测特定特征。然而，感官知觉、意识和认知是从信息的组合中产生的。在这里，我们分析了猫的皮质网络，寻找允许大脑中信息同时分离和整合的解剖学基础。我们发现皮层通信主要受底层网络的三个拓扑因素控制：（i）连接密度大，（ii）皮层区域分成簇，以及（iii）高度连接的枢纽的存在有助于多感官处理和整合。最短路径的统计分析表明，虽然所有皮层区域都可以轻松访问信息，但皮层信息处理的复杂性可能源于丰富而复杂的替代路径，这些区域可以相互影响。
Sensory information entering the nervous system follows independent paths of processing such that specific features are individually detected. However, sensory perception, awareness, and cognition emerge from the combination of information. Here we have analyzed the corticocortical network of the cat, looking for the anatomical substrate which permits the simultaneous segregation and integration of information in the brain. We find that cortical communications are mainly governed by three topological factors of the underlying network: (i) a large density of connections, (ii) segregation of cortical areas into clusters, and (iii) the presence of highly connected hubs aiding the multisensory processing and integration. Statistical analysis of the shortest paths reveals that, while information is highly accessible to all cortical areas, the complexity of cortical information processing may arise from the rich and intricate alternative paths in which areas can influence each other.