PAIN-RELATED SOMATOSENSORY EVOKED-POTENTIALS FOLLOWING CO2-LASER STIMULATION IN MAN
PAIN-RELATED SOMATOSENSORY EVOKED-POTENTIALS FOLLOWING CO2-LASER STIMULATION IN MAN
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DOI：
10.1016/0168-5597(89)90019-1
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发表时间：
1989-03-01
期刊：
影响因子：
--
通讯作者：
IKEDA, A
中科院分区：
文献类型：
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作者：
KAKIGI, R;SHIBASAKI, H;IKEDA, A
分析了正常志愿者CO2激光刺激后的痛觉诱发电位(SEP)。低功率、长波长的CO2激光刺激手部会引起剧烈的疼痛，这与头皮上记录到的一个大的正性成分P320有关。随着刺激强度和主观痛感的降低，波幅降低，潜伏期延长。P320在头顶最大，但广泛分布于头皮。左手刺激和右手刺激、手刺激和胸部刺激之间没有地形图差异。注射利多卡因产生麻醉性神经阻滞，导致P320消失，但在缺血性神经阻滞时，P320相对保留。在电或机械触觉刺激后，不能记录到对应于P320的电位。我们认为P320是由疼痛刺激产生的冲动产生的，并通过Aβ上升。纤维。考虑到丘脑的头皮地形图，我们认为丘脑是一个生成源，但疼痛特有的认知或知觉也可能参与生成这种潜力。
Pain-related somatosensory evoked potentials (SEPs) following CO2 laser stimulation were analyzed in normal volunteers. Low power and long wavelength CO2 laser stimuli to the hand induced a sharp pain which was associated with a large positive component, P320, recorded over the scalp. Amplitude decreased and latency increased with reduction in stimulus intensity and subjective pain feeling. P320 was maximal at the vertex but was distributed widely over the scalp. There were no topographic differences between left- and right-hand stimulation, or between hand and chest stimulation. Lidocaine injection to produce anesthetic nerve block resulted in loss of P320, but the potential was relatively preserved during ischemic nerve block. No potential corresponding to P320 could be recorded following electrical or mechanical tactile stimulation. We consider P320 to be generated by impulses arising from pain stimuli and ascending through A.delta. fibers. We propose the thalamus as a generator source from considering its scalp topography, but pain-specific cognition or perception may also be involved in generating this potential.