Magnetic Resonance-Guided Focused Ultrasound for Psychiatric Disorders
Magnetic Resonance-Guided Focused Ultrasound for Psychiatric Disorders
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DOI：
10.1002/cpt.1467
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发表时间：
2019-10-01
影响因子：
6.7
通讯作者：
Lipsman, Nir
中科院分区：
文献类型：
--
作者：
Davidson, Benjamin;Meng, Ying;Lipsman, Nir
磁共振成像引导的聚焦超声(MRgFUS)是一项新兴的技术，可以在不进行开放手术的情况下在大脑内创建精确的立体定向病变。MRgFUS是一种新兴的治疗方法，在临床神经科学中迅速被采用。[4]在该过程中，患者在局部麻醉下使用立体定向框架，然后将其连接到内衬有1,024个小型超声换能器的头盔(B图b)。MRgFUS丘脑切开术最近已成为治疗特发性震颤的既定疗法，在一项成功的随机安慰剂对照试验治疗顽固性中到重度特发性震颤患者后，于2016年获得美国食品和药物管理局和加拿大卫生部的批准。[4]因此，MRgFUS丘脑切除术目前正在研究其他条件下的MRgFUS消融手术，包括治疗抵抗的精神疾病，在这些情况下，产生损伤可能是有益的。[5].[摘自文章]《临床药理学与治疗》版权归Wiley-Blackwell所有，未经版权所有者明确书面许可，不得将其内容复制或通过电子邮件发送到多个站点或发布到列表服务器。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这篇摘要可以删节。对复制品的准确性不作任何保证。用户应参考该材料的原始出版版本，以获取完整摘要。版权适用于所有摘要。
Magnetic resonance imaging-guided focused ultrasound (MRgFUS) is an emerging technology that can be used to create precise stereotactic lesions within the brain without an open surgery. MRgFUS is an emerging treatment modality quickly being adopted worldwide in the clinical neurosciences.[4] During the procedure, patients have a stereotactic frame applied under local anesthetic, which is then connected to a helmet lined with 1,024 small ultrasound transducers (B Figure b). MRgFUS thalamotomy has recently become an established treatment for essential tremor, gaining the US Food and Drug Administration and Health Canada approval in 2016 after a successful randomized placebo-controlled trial treating patients with refractory moderate-to-severe essential tremor.[4] As a result, MRgFUS ablative procedures are currently being investigated in other conditions, including treatment-resistant psychiatric conditions, where generating a lesion may be beneficial.[[2],[5]].[Extracted from the article]Copyright of Clinical Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.