Cognitive rehabilitation as a component of early intervention in Alzheimer s disease: a single case study
Cognitive rehabilitation as a component of early intervention in Alzheimer s disease: a single case study
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DOI：
10.1080/1360786021000045854
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发表时间：
2003-01-01
影响因子：
3.4
通讯作者：
Hodges, JR
中科院分区：
文献类型：
--
作者：
Clare, L;Wilson, BA;Hodges, JR
阿尔茨海默病（AD）的早期干预应侧重于心理和社会需求以及药物的提供。早期AD患者早期干预计划的一个可能组成部分是认知康复，旨在促进制定应对记忆问题的策略。认知康复在早期AD中的可能相关性得到了神经心理学和实验学习研究的支持，但需要进一步的工作来开发临床相关的干预措施，这些干预措施可以应用于现实生活中。本文提出了一个单一的案例干预研究，其中一个66岁的男子与早期AD学习的名字，他的支持小组使用记忆策略，加上扩大排练或重复演示，或两者兼而有之，在一个无误的学习范式。回忆分数从初始基线的平均2.31%提高到干预后的91.46%，并且在随访中基本保持了增长。在干预期间，没有证据表明抑郁、焦虑或照顾者压力增加。结果支持这样的观点，即认知康复干预可能是AD患者综合早期干预计划的重要组成部分。
Early intervention in Alzheimer's disease ( AD) should focus on psychological and social needs as well as the provision of medication. One possible component of early intervention programmes for people with early-stage AD is cognitive rehabilitation aimed at fostering the development of strategies for coping with memory problems. The likely relevance of cognitive rehabilitation in early-stage AD is supported by neuropsychological and experimental learning studies, but further work is required to develop clinically relevant interventions, which can be applied in the real-life setting. This paper presents a single case intervention study in which a 66-year-old man with early-stage AD learned the names of 13 members of his support group using a mnemonic strategy coupled with either expanding rehearsal or repeated presentation, or both, within an errorless learning paradigm. Recall scores improved from a mean of 2.31% at initial baseline to 91.46% following intervention, and gains were largely maintained at follow-up. There was no evidence of any increase in depression, anxiety or caregiver strain during the intervention. The results support the view that cognitive rehabilitation interventions may form a valuable component of comprehensive early intervention programmes for people with AD.