Osteoarthritis is a serious disease.
Osteoarthritis is a serious disease.
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DOI：
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发表时间：
2019-09
影响因子：
3.7
通讯作者：
G. Hawker
中科院分区：
文献类型：
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作者：
G. Hawker
骨关节炎（OA）是最常见的关节炎，65岁以上人群中有三分之一受其影响，女性比男性多。OA的患病率正在上升，部分原因是OA危险因素的患病率增加，包括肥胖、缺乏运动和关节损伤。与oa相关的关节疼痛会导致功能限制、睡眠不良、疲劳、情绪低落和丧失独立性。与年龄和性别匹配的同龄人相比，OA患者由于失去生产力而产生更高的自付健康支出和大量费用。大多数OA患者（59-87%）至少有一种其他慢性疾病，尤其是心脏代谢疾病。症状性OA可能会损害心脏代谢疾病患者运动和减肥的能力，导致不良预后的风险增加。患有OA和其他慢性疾病的人接受诊断或推荐治疗的可能性较小。此外，对这些人来说，最有效和最安全的治疗方法是身体活动/锻炼与自我管理策略相结合，这只是适度有效。鉴于OA的负担已经很高，而且还在不断增加，需要加大努力，为大多数患有其他慢性疾病的OA患者确定更好、更有效和更安全的治疗方法。
Osteoarthritis (OA) is the most common form of arthritis, affecting 1 in 3 people over age 65 and women more so than men. The prevalence of OA is rising due, in part, to the increasing prevalence of OA risk factors, including obesity, physical inactivity, and joint injury. OA-related joint pain causes functional limitations, poor sleep, fatigue, depressed mood and loss of independence. Compared to age and sex-matched peers, OA patients incur higher out of pocket health-related expenditures and substantial costs due to lost productivity. Most people with OA (59-87%) have at least one other chronic condition, especially cardiometabolic conditions. Symptomatic OA may impair the ability of people with cardiometabolic conditions to exercise and lose weight, resulting in increased risk for poor outcomes. People with OA and other chonic conditions are less likely to receive a diagnosis or recommended treatment. Further, in these individuals the most effective and safest treatment is physical activity/exercise coupled with self-management strategies, which is only moderately effective. Given the already high, and growing, burden of OA, enhanced effort is required to identify better - more effective and safe - treatments for the majority of people with OA who are living with other chronic conditions.