Mechanism of incomplete mitral leaflet coaptation - Interaction of chordal restraint and changes in mitral leaflet coaptation geometry - Insight from in vitro validation of the premise of force equilibrium
Mechanism of incomplete mitral leaflet coaptation - Interaction of chordal restraint and changes in mitral leaflet coaptation geometry - Insight from in vitro validation of the premise of force equilibrium
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DOI：
10.1115/1.1500741
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发表时间：
2002-10-01
影响因子：
1.7
通讯作者：
Yoganathan, AP
中科院分区：
文献类型：
--
作者：
Nielsen, SL;Nygaard, H;Yoganathan, AP
通过改变腱索栓系和腱索接合力分量的平衡，在体外重现了临床观察到的二尖瓣瓣叶不完全接合。乳头肌和二尖瓣之间的空间关系以及血流动力学的变化导致二尖瓣瓣叶对合几何形状扭曲。腱索系留和接合力分量的重新分布加重了二尖瓣瓣叶对线不良。对于交界性二尖瓣返流中收缩期二尖瓣瓣叶构型的总体评估，重要的是要考虑腱索限制和二尖瓣瓣叶接合几何形状改变之间的相互作用。
Clinically observed incomplete mitral leaflet coaptation was reproduced in vitro by altering the balance of the chordal tethering and chordal coapting force components. Mitral leaflet coaptation geometry was distorted by changes of the spatial relations between the papillary muscles and the mitral valve as well as hemodynamics. Mitral leaflet malalignment was accentuated by a redistribution of the chordal tethering and coapting force components. For the overall assessment of systolic mitral leaflet configuration in Junctional mitral regurgitation it is important to consider the interaction between chordal restraint and an altered mitral leaflet coaptation geometry.