Bed nucleus of the stria terminalis subregions differentially regulate hypothalamic-pituitary-adrenal axis activity: Implications for the integration of limbic inputs
Bed nucleus of the stria terminalis subregions differentially regulate hypothalamic-pituitary-adrenal axis activity: Implications for the integration of limbic inputs
复制标题
DOI：
10.1523/jneurosci.4301-06.2007
复制
发表时间：
2007-02-21
影响因子：
5.3
通讯作者：
Herman, James P.
中科院分区：
文献类型：
--
作者：
Choi, Dennis C.;Furay, Amy R.;Herman, James P.
边缘和皮质神经回路深刻地影响下丘脑-垂体-肾上腺（HPA）轴对应激的反应，但很少或没有直接投射到下丘脑室旁核（PVN）。大量证据表明，终纹床核（BST）的位置很好，可以将边缘系统的信息传递给PVN。BST由多个解剖学上不同的核团组成，已知其中一些核团接收直接边缘和/或皮质输入并严重神经支配PVN。我们的研究测试的假设，BST的亚区差异调节HPA轴对急性应激的反应。雄性Sprague道利大鼠接受双侧鹅膏齿状核损伤，靶向后部BST中的主核或前腹侧BST中的背内侧/梭状核。相对于假损伤动物，后BST损伤升高了对急性束缚应激的血浆ACTH和皮质酮，增加了应激诱导的PVN c-fos mRNA，以及升高的PVN促肾上腺皮质激素释放激素（CRH）和小细胞精氨酸加压素（AVP）mRNA表达。相反，前BST损伤减弱了血浆皮质酮反应，降低了PVN中c-fos mRNA的诱导，但不影响PVN中CRH和小细胞AVP mRNA的表达。这些数据表明，后BST核参与HPA轴的抑制，而前腹侧BST核参与HPA轴的兴奋。结果表明，BST包含的功能子域，发挥不同的作用，在整合和处理边缘系统的信息，在应对压力，并进一步表明，兴奋性以及抑制性边缘系统的信息是通过这些重要的细胞群漏斗。
Limbic and cortical neurocircuits profoundly influence hypothalamic - pituitary - adrenal ( HPA) axis responses to stress yet have little or no direct projections to the hypothalamic paraventricular nucleus ( PVN). Numerous lines of evidence suggest that the bed nucleus of the stria terminalis ( BST) is well positioned to relay limbic information to the PVN. The BST comprises multiple anatomically distinct nuclei, of which some are known to receive direct limbic and/ or cortical input and to heavily innervate the PVN. Our studies test the hypothesis that subregions of the BST differentially regulate HPA axis responses to acute stress. Male Sprague Dawley rats received bilateral ibotenate lesions, targeting either the principal nucleus in the posterior BST or the dorsomedial/ fusiform nuclei in the anteroventral BST. Posterior BST lesions elevated plasma ACTH and corticosterone in response to acute restraint stress, increased stress- induced PVN c-fos mRNA, and elevated PVN corticotropin- releasing hormone ( CRH) and parvocellular arginine vasopressin ( AVP) mRNA expression relative to sham- lesion animals. In contrast, anterior BST lesions attenuated the plasma corticosterone response and decreased c- fos mRNA induction in the PVN but did not affect CRH and parvocellular AVP mRNA expression in the PVN. These data suggest that posterior BST nuclei are involved in inhibition of the HPA axis, whereas the anteroventral BST nuclei are involved in HPA axis excitation. The results indicate that the BST contains functional subdomains that play different roles in integrating and processing limbic information in response to stress and further suggest that excitatory as well as inhibitory limbic information is funneled through these important cell groups.