Serum Alpha-1 Antitrypsin Levels and the Clinical Course of Chronic Obstructive Pulmonary Disease
Serum Alpha-1 Antitrypsin Levels and the Clinical Course of Chronic Obstructive Pulmonary Disease
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DOI：
10.2147/copd.s225365
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发表时间：
2019-01-01
影响因子：
2.8
通讯作者：
Nishimura, Masaharu
中科院分区：
文献类型：
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作者：
Takei, Nozomu;Suzuki, Masaru;Nishimura, Masaharu
目的：α-1抗胰蛋白酶缺乏与慢性阻塞性肺疾病(COPD)的发展有关，而血清α-1抗胰蛋白酶水平升高则是炎症反应的结果。α-1抗胰蛋白酶水平对COPD临床病程的影响尚不清楚。基于10年前瞻性队列研究的数据，我们调查了血清α-1抗胰蛋白酶水平与COPD患者临床病程的关系。患者和方法：我们分析了参加北海道COPD队列研究的278名不符合α-1抗胰蛋白酶缺乏标准的COPD患者。我们根据基线时血清α-1抗胰蛋白酶水平的四分位数将受试者分为三组：较低组(
Purpose: Alpha-1 antitrypsin deficiency is associated with the development of chronic obstructive pulmonary disease (COPD), whereas increased levels of serum alpha-1antitrypsin occur in response to inflammation. The effects of alpha-1 antitrypsin levels on the clinical course of COPD had been unclear. We investigated the association of serum alpha-1 antitrypsin levels with the clinical course of COPD patients based on data from a 10-year prospective cohort study.Patients and methods: We analyzed 278 COPD patients who participated in the Hokkaido COPD cohort study and who did not meet the criteria for alpha-1 antitrypsin deficiency. We divided the subjects into 3 groups according to quartiles of serum alpha-1 antitrypsin levels at baseline: lower group (