Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures
Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures
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DOI：
10.1359/jbmr.1999.14.6.960
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发表时间：
1999-06-01
影响因子：
6.2
通讯作者：
Oxlund, H
中科院分区：
文献类型：
--
作者：
Andreassen, TT;Ejersted, C;Oxlund, H
本文观察了大鼠胫骨骨折愈合后20天和40天，间歇性给予甲状旁腺激素（PTR（1-34））对骨痂形成和力学强度的影响。在整个愈合期间分别给予60 μ g PTH（1-34）kg/天和200 μ g PTH（1-34）kg/天的剂量，并且给予骨折的对照动物赋形剂。200 μ g PTH（1-34）/kg/天的剂量在愈合20天后使骨折的极限负荷和外部骨痂体积分别增加了75%和99%，在愈合40天后分别增加了175%和72%。60 μ g PTH（1-34）/kg/天的剂量在愈合20天后对骨折的极限载荷或外部骨痂体积均无影响，但在愈合40天后，极限载荷增加了132%，外部骨痂体积增加了42%。在愈合期间，所有组的骨痂骨矿物质含量（BMC）增加。愈合40天后，200 μ g PTH（1-34）/kg/天组的骨痂BMC增加了108%，60 μ g PTH（1-34）/kg/天组增加了76%，两种剂量的PTH（1-34）均稳定地增加了对侧完整胫骨BMC（20天和40天：60 μ g PTH（1-34）/kg/天分别为9%和19%; 200 μ g PTH（1-34）/kg/天分别为12%和27%）和骨矿物质密度（20天和40天：60 μ g PTH（1-34）/kg/天分别为11%和12%; 200 μ g PTH（1-34）/kg/天分别为11%和15%）。
The influence of intermittent parathyroid hormone (PTR(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 mu g of PTH(1-34)kg/day and 200 mu g of PTH(1-34)/kg/day, respectively, was administered during the entire periods of healing, and control animals with fractures were given vehicle. The dose of 200 mu g of PTH(1-34)/kg/day increased the ultimate load and the external callus volume of the fractures by 75% and 99%, respectively, after 20 days of healing and by 175% and 72%, respectively, after 40 days of healing. The dose of 60 mu g of PTH(1-34)/kg/day did not influence either ultimate load or external callus volume of the fractures after 20 days of healing, but the ultimate load was increased by 132% and the external callus volume was increased by 42% after 40 days of healing. During the healing period, the callus bone mineral content (BMC) increased in all groups, After 40 days of healing, the callus BMC was increased by 108% in the 200 mu g of PTH(1-34)/kg/day group and by 76% in the 60 mu g of PTH(1-34)/kg/day group, Both doses of PTH(1-34) steadily augmented the contralateral intact tibia BMC (20 days and 40 days: 60 mu g of PTH (1-34)/kg/day 9% and 19%, respectively; 200 mu g of PTH (1-34)/kg/day 12% and 27%, respectively) and bone mineral density (20 days and 40 days: 60 mu g of PTH(1-34)/kg/day 11% and 12%, respectively; 200 mu g of PTH(1-34)/kg/day 11% and 15%, respectively).