New insights into germ cell tumor formation.
New insights into germ cell tumor formation.
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对生殖细胞肿瘤形成的新见解。
DOI：
10.1055/s-2008-1073168
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Jessberger,R
中科院分区：
文献类型：
--
作者：
Jessberger,R
近年来出现了许多新发现，对我们理解生殖细胞肿瘤的发展具有重要意义。本次通讯回顾了一些最近的见解，重点关注可能将生殖细胞转化为肿瘤细胞的机制。本文从三个方面进行了讨论：(1)生殖细胞肿瘤的早期起源是原始生殖细胞通过异常的有丝分裂到减数分裂的转换；(2)减数分裂过程中的错误促进了生殖细胞的致瘤性转化；(3)生殖细胞肿瘤的发生。 (3)小RNA如oncomirs (miRNA)和oncopirs (piRNA)在生殖细胞肿瘤形成中的作用。由于使用各种生物模型已经了解了很多，因此将考虑在小鼠、线虫、果蝇和人类实验中获得的数据。仅包括示例性参考文献。
Recent years have witnessed a number of new findings with significant implications for our understanding of the development of germ cell tumors. This communication reviews some of these recent insights with an emphasis on mechanisms that may convert a germ cell into a tumor cell. Three aspects are discussed in this review:(1) the early origin of germ cell tumors from primordial germ cells through an aberrant mitosis-to-meiosis switch;(2) errors during meiosis, which promote tumorigenic transformation of germ cells; and (3) the role of small RNAs such as oncomirs (miRNAs) and oncopirs (piRNAs) in germ cell tumor formation. Since much has been learned using a variety of organismal models, data obtained in experiments with mice, nematodes, fruit flies, and human data will be considered. Only exemplary references are included.