Hippocampus's role in forming "task-related" associations: Flashing to the things you are looking for
Hippocampus's role in forming "task-related" associations: Flashing to the things you are looking for
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海马在形成“任务相关”联想中的作用：闪现出你正在寻找的东西
DOI：
10.1007/s11434-008-0321-6
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发表时间：
2008
影响因子：
--
通讯作者：
Luo Jing
中科院分区：
文献类型：
--
作者：
Zhang XiuLing;Kazuhisa NIKI;Luo Jing
Eichenbaum和他的同事们观察到，同一个地方是否激活了海马体中的“目标接近”细胞，取决于这个地方是否是老鼠接近特定目标的方式。与此同时，目前的神经影像学研究表明，当同一类型的项目与手头的任务相关时，海马会比与手头的任务无关时激活更多。当参与者对单词对中包含的关系类型做出判断时（例如，单词对“category-table”是否包含“category-exemplar”关系？）事件相关分析表明，即使是同一类型的项目，“任务相关”联想的形成也比“任务无关”联想的形成激活更多的海马，这种海马差异不是由不同的判断要求引起的，也不是由“是”反应的影响引起的。结果表明，在判断后线索回忆测验中，与任务无关的联想比与任务相关的联想具有更好的提取效果。结果还表明，要关联的单个词之间的语义相关性（例如，相关词对“healthy-hospital”与不相关词对“price-way”）在“任务不相关”时不足以激活海马体。总体而言，我们认为海马通过参与任务相关联想的形成和情景记忆的巩固，使生物体能够记住具有重要生存价值的信息以供将来使用。
Eichenbaum and colleagues observed that the same place did or did not activate the “goal-approach” cells in hippocampus depending on whether the place was the way for rats to approach specific goal. Parallel with this, the present neuroimage study revealed that, the same type of items could activate the hippocampus more when it was related to the task at hand than when it not. Participants were scanned by fMRI while they made judgments on the type of relationships contained in the word-pairs (e.g., Does the word pair, “furniture-table”, contain a “category-exemplar” relationship?). Event-related analysis revealed that the forming of “task-related” association activated hippocampus more than that of “task-unrelated”, even if it was the same type of items, and, this hippocampal difference was not caused by the different judgment requirements, nor by the effects of “yes” response. Consistently, the post-judgment cued-recall test exhibited a better retrieval performance for “task-related” associations than for the same type but “task-unrelated” associations. Results also showed that, the semantic relatedness between the to-be-associated individual words (e.g., the related word pair “healthy-hospital” versus the unrelated word pair “price-way”) was not enough to activate the hippocampus when it was “task-unrelated”. Generally, we proposed that, through participating in forming of “task-related” associations and consolidating of episodic memory, hippocampus enabled the organism to keep the information that owned great survival values in mind for future usage.