Chemical modification of heparin and heparosan.
Chemical modification of heparin and heparosan.
复制标题
肝素和肝素的化学修饰。
DOI：
10.1007/978-1-4939-1714-3_4
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Arungundram,Sailaja
中科院分区：
文献类型：
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作者：
Raman,Karthik;Kuberan,Balagurunathan;Arungundram,Sailaja
肝素是一种有效的临床抗凝剂。它是含有各种硫酸化模式的聚合物的非均相混合物。然而，只有3-O磺化肝素五糖单位已被证明结合抗凝血酶，并引起抗凝反应。具有其他硫酸化模式的肝素能够结合多种其他蛋白质，如FGF、VEGF和CXCL-3。通过调节肝素的硫酸化模式，有可能产生可以调节止血以外的生物过程的聚合物。本文介绍了几种简单的化学修饰方法，N-乙酰化、N-脱乙酰化、N-硫酸化、O-硫酸化、2-乙酰化和完全硫酸化，制备了具有不同硫酸化模式的类肝素聚合物。
Heparin is a potent clinically used anticoagulant. It is a heterogeneous mixture of polymers that contain a variety of sulfation patterns. However, only 3-Osulfonated heparin pentasaccharide units have been proven to bind to antithrombin and elicit an anticoagulant response. Heparins with other sulfation patterns are able to bind to a variety of other proteins such as FGF, VEGF, and CXCL-3. By modulating heparin’s sulfation pattern, it is possible to generate polymers that can regulate biological processes beyond hemostasis. Here we describe a variety of simple chemical modification methods,N-acetylation,N-deacetylation,N-sulfation,O-sulfation, 2-Odesulfation, and complete desulfation, to prepare heparin-like polymers with distinct sulfation patterns.