Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications.
Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications.
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DOI：
10.3390/cancers13225633
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发表时间：
2021-11-11
期刊：
影响因子：
5.2
通讯作者：
Nana-Sinkam P
中科院分区：
文献类型：
--
作者：
Saviana M;Romano G;Le P;Acunzo M;Nana-Sinkam P
众所周知，癌细胞与周围的细胞外环境相互作用，促进肿瘤的形成过程。癌细胞之间相互联系的一种机制是通过细胞外小泡。这些囊泡含有各种生物分子，由亲本细胞分泌，然后输送到目标受体细胞。在过去的几十年里，对细胞外小泡的结构和内容的了解为肿瘤生物学提供了宝贵的见解。考虑到这些信息，研究人员已经开始研究这些囊泡用于开发新的生物标记物分类器以及治疗策略的潜力。细胞外小泡(EVS)是由每个细胞分泌到细胞外环境中的异质膜囊泡。EV携带生物活性分子，包括蛋白质、脂类、DNA和不同的RNA形式，这些分子可以被受体细胞内化，从而改变它们的生物学特性。鉴于EV普遍存在于大多数体液中，它们被广泛描述为包括癌症在内的几个生理和病理过程中的沟通媒介。此外，它们很容易在生物液中被检测到，这使它们成为潜在的有用的肿瘤生物标记物。在这篇手稿中，我们回顾了目前关于EVS和非编码RNA的知识，以及它们在肺癌转移过程中的作用。此外，我们介绍了EVS和非编码RNA作为癌症治疗的最新应用，以及它们作为临床生物标记物的相关性。
Cancer cells are known to interact with the surrounding extracellular environment to facilitate tumorigenic processes. One mechanism by which cancer cells communicate with each other and their environment is through extracellular vesicles. These vesicles contain various biological molecules that are secreted by parental cells for delivery to target recipient cells. Over the past several decades, knowledge of the structure and contents of extracellular vesicles has provided valuable insight into tumor biology. Considering this information, researchers have begun examining the potential of these vesicles for developing novel biomarker classifiers as well as therapeutic strategies. Extracellular vesicles (EVs) are heterogenous membrane-encapsulated vesicles secreted by every cell into the extracellular environment. EVs carry bioactive molecules, including proteins, lipids, DNA, and different RNA forms, which can be internalized by recipient cells, thus altering their biological characteristics. Given that EVs are commonly found in most body fluids, they have been widely described as mediators of communication in several physiological and pathological processes, including cancer. Moreover, their easy detection in biofluids makes them potentially useful candidates as tumor biomarkers. In this manuscript, we review the current knowledge regarding EVs and non-coding RNAs and their role as drivers of the metastatic process in lung cancer. Furthermore, we present the most recent applications for EVs and non-coding RNAs as cancer therapeutics and their relevance as clinical biomarkers.
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影响因子：
--
作者：
Bae GY;Choi SJ;Lee JS;Jo J;Lee J;Kim J;Cha HJ
通讯作者：
Cha HJ
影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
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Wood, Matthew J. A.
影响因子：
5.2
作者：
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通讯作者：
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影响因子：
11.2
作者：
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通讯作者：
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影响因子：
4.6
作者：
Brennan, K.;Martin, K.;Mc Gee, M. M.
通讯作者：
Mc Gee, M. M.