Psychoneuroimmunoendocrinology: the biological basis of mind-body physiology and pathophysiology.
Psychoneuroimmunoendocrinology: the biological basis of mind-body physiology and pathophysiology.
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心理神经免疫内分泌学：身心生理学和病理生理学的生物学基础。
DOI：
10.1002/da.22110
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发表时间：
2013
影响因子：
7.4
通讯作者：
Nemeroff,CharlesB
中科院分区：
文献类型：
--
作者：
Nemeroff,CharlesB
我为这篇文章的标题创造了这个新词，心理神经免疫内分泌学，它包含了我们现在所知道的作为哺乳动物生物体中主要通讯系统的主要学科--内分泌系统、神经系统和免疫系统。这些复杂的网络与来自心理过程的输入一起相互通信，监测和调节各种内部生理功能，并警惕地防范内部和外部威胁。尽管现在即使是刚开始的医学生和研究生也认为这几乎是初级的，但这些系统之间的串扰定期发生并导致疾病易感性的概念并没有被我们领域的领导者广泛接受，甚至就在几十年前。包括抑郁和焦虑的这个特刊的手稿，基于两个研讨会（焦虑和医学疾病之间的界面，以及整合身心联系），在美国焦虑和抑郁协会（ADAA）的2012年年会上提出，代表了这个新兴领域的一些前沿研究的例子。应主编的要求，我试图将这些报告的内容与我自己对这一学科的一些小贡献结合起来，以突出这一领域在现在所谓的“个性化医疗”发展中所起的重要作用。我将简要地集中在我的三个研究领域：抑郁症对心血管疾病（CVD）风险的影响及其对疾病结局的不利影响，抑郁症对癌症进展的影响，最后是儿童虐待和忽视对成年后医疗和精神疾病风险的影响。这些研究项目中的每一个都是行为因素与神经、内分泌和免疫系统相互作用的象征。由于篇幅所限，无法对这些复杂的多学科研究领域进行全面讨论，并为更感兴趣的读者提供参考。如果没有三个主要因素，
This neologism I created for the title of this essay, psychoneuroimmunoendocrinology, encompasses the major disciplines that we now know serve as the major communication systems in mammalian organisms—the endocrine, nervous, and immune systems. Together with input from psychological processes, these complex networks communicate with each other monitoring and regulating a variety of internal physiological functions, as well as vigilantly guarding against internal and external threats. Although now considered virtually elementary by even beginning medical and graduate students, the notion that crosstalk between these systems occurs on a regular basis and contributes to disease vulnerability was not largely accepted by leaders in our field even as recently as a few decades ago. The manuscripts that comprise this special issue of Depression and Anxiety, based on two symposia (The Interface Between Anxiety and Medical Disorders, and Integrating Mind–Body Connections) that were presented at the 2012 Annual Meeting of the Anxiety and Depression Association of America (ADAA), represent examples of some of the cutting-edge research in this now burgeoning area. As requested by the Editor-in-Chief, I have attempted to combine the content of these reports with some of my own small contributions to this discipline to highlight the important role this field plays in the development of what is now called “personalized medicine.” I will briefly focus on three of my research areas: the effects of depression on both risk for cardiovascular disease (CVD) and its untoward effects on disease outcome, the effects of depression on cancer progression, and finally the effects of child abuse and neglect on risk for medical and psychiatric disorders in adulthood. Each of these research programs is emblematic of the interaction of behavioral factors with the nervous, endocrine, and immune systems. Space constraints preclude a comprehensive discussion of these complex multidisciplinary research areas and references are provided for the more interested readers. None of this work of mine could have possibly been launched without three major factors—the