Requirement for microtubules in new membrane formation during cytokinesis of Xenopus embryos
Requirement for microtubules in new membrane formation during cytokinesis of Xenopus embryos
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DOI：
10.1006/dbio.1997.8815
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发表时间：
1998-02-01
影响因子：
2.7
通讯作者：
Larkin, K
中科院分区：
文献类型：
--
作者：
Danilchik, MV;Funk, WC;Larkin, K
在非洲爪哇卵的分裂中，暴露在诺可达唑或冷休克中会阻止新的质膜添加到卵裂面，并导致皱纹后退，这表明微管在细胞质分裂中具有特殊的作用。整体共聚焦免疫细胞化学显示，从第一次卵裂到中期囊胚，在所有推进的卵裂沟的底部，都有一圈放射状排列的乙酰化微管束。我们推测，这种新的微管结构参与了将皮层下母体储存的膜运输到沟槽前缘附近的膜添加位置。(C)1998年学术出版社。
In cleaving Xenopus eggs, exposure to nocodazole or cold shock prevents the addition of new plasma membrane to the cleavage plane and causes furrows to recede, suggesting a specific role for microtubules in cytokinesis. Whole-mount confocal immunocytochemistry reveals a ring of radially arranged, acetylated microtubule bundles at the base of all advancing cleavage furrows, from the first cleavage through the midblastula stage. We hypothesize that this novel microtubular structure is involved in transporting maternal stores of membrane in the subcortex to a site of membrane addition near the leading edge of the furrow. (C) 1998 Academic Press.