Could head circumference be used to screen for autism in young males with developmental delay?
Could head circumference be used to screen for autism in young males with developmental delay?
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DOI：
10.1111/j.1440-1754.2011.02238.x
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发表时间：
2012-04-01
影响因子：
1.7
通讯作者：
Tonge, Bruce J.
中科院分区：
文献类型：
--
作者：
Gray, Kylie M.;Taffe, John;Tonge, Bruce J.
目的：研究表明，自闭症儿童在出生后的头12个月内，头围的增长会异常加速。本研究旨在探讨自闭症伴发育迟缓幼儿和无自闭症伴发育迟缓幼儿出生时的头围和头围增长速度。方法：本研究评估了86例自闭症幼儿和40例发育迟缓无自闭症儿童出生时的头围及头围变化率。结果：两组儿童出生时的头围和头围生长均与疾病控制中心的规范数据进行了比较。有自闭症和发育迟缓的儿童与只有发育迟缓的儿童相比，没有发现任何差异。然而，当样本与选定的疾病控制中心标准中值进行比较时，发现自闭症儿童在出生时头围明显较小，在18.5个月大时头围明显较大。结论：这些结果讨论了加速头围增长作为自闭症早期标志的潜力。本研究未发现自闭症伴发育迟缓儿童和仅发育迟缓儿童的头围有差异，提示测量头围作为自闭症早期标志物的价值有限。
Aim: Research has suggested an abnormal acceleration in head circumference growth in children with autism within the first 12 months of life. This study aimed to examine head circumference at birth and head circumference growth rates in young children with autism and developmental delay, and young children with developmental delay without autism.Methods: This study assessed head circumference at birth and rate of change in head circumference in young children with autism (n = 86) and children with developmental delay without autism (n = 40).Results: For both groups of children, head circumference at birth and head circumference growth were compared with Centers for Disease Control normative data. No differences were found between the group of children with autism and developmental delay compared with the group with developmental delay only. However, when the sample was compared with a range of selected Centers for Disease Control normative medians, the children with autism were found to have significantly smaller head circumferences at birth and significantly larger head circumference at 18.5 months of age.Conclusions: These results are discussed in relation to the potential of accelerated head circumference growth as an early marker for autism. This study failed to find a difference in the head circumferences of children with autism and developmental delay and children with developmental delay only, thus suggesting that head circumference measurement has limited value as an early marker for autism.