Apoptosis enhanced by soluble factor produced in feline immunodeficiency virus infection
Apoptosis enhanced by soluble factor produced in feline immunodeficiency virus infection
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DOI：
10.1292/jvms.59.1049
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发表时间：
1997-11-01
影响因子：
1.2
通讯作者：
Hasegawa, A
中科院分区：
文献类型：
--
作者：
Mizuno, T;Momoi, Y;Hasegawa, A
猫免疫缺陷病毒（FIV）感染的细胞已显示通过用肿瘤坏死因子α（TNF-cr）处理而经历凋亡。本研究检测到一种可溶性因子，其增强TNF-cr处理诱导的细胞凋亡。当将FIV感染的CRFK细胞的培养上清液或来自FIV感染的猫的血浆样品添加到培养物中时，在猫成纤维细胞样细胞系（CRFK）细胞中诱导凋亡对TNF-cr的敏感性显著增强。这些结果表明，FIV感染诱导产生的可溶性因子，增强CRFK细胞的敏感性，TNF-cr诱导细胞凋亡在体外和体内。这一因素可能导致感染FIV的猫的淋巴细胞丢失。
Feline immunodeficiency virus (FIV)-infected cells have been shown to undergo apoptosis by treatment with tumor necrosis factor alpha(TNF-cr). This study detected a soluble factor which enhanced the apoptosis induced by TNF-cr treatment. The sensitivity to TNF-cr in the induction of apoptosis in a feline fibroblastoid cell line (CRFK) cells was significantly enhanced when the culture supernatant of FIV-infected CRFK cells or plasma samples from FIV-infected cats was added to the culture. These findings suggested that FIV infection induces production of a soluble factor which enhances CRFK cells sensitivity to TNF-cr induction of apoptosis both in vitro and in vivo. This factor may contribute to the loss of lymphocytes in cats infected with FIV.