Branched chain fatty acids are constituents of the normal healthy newborn gastrointestinal tract.
Branched chain fatty acids are constituents of the normal healthy newborn gastrointestinal tract.
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DOI：
10.1203/pdr.0b013e318184d2e6
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发表时间：
2008-12
影响因子：
3.6
通讯作者：
Brenna JT
中科院分区：
文献类型：
--
作者：
Ran-Ressler RR;Devapatla S;Lawrence P;Brenna JT
悬浮在羊水中的胎脂通常被晚期胎儿吞下。我们假设支链脂肪酸（BCFA），长期以来被认为是主要的胎粪成分，将被发现在胎粪和配置文件将系统地不同。从足月新生儿中收集胎粪和胎粪并进行分析。含BCFA的脂质占胎脂干重的约12%，并且主要是饱和的，并且每个BCFA具有11至26个碳。相比之下，胎粪BCFA具有16至26个碳，约占干重的1%。胎粪BCFA主要是在异构型，而胎粪BCFA含有二甲基和中链分支，和5 anteiso BCFA。在妊娠的最后一个月，作为吞咽的胎粪颗粒进入胎儿肠道的BCFA的质量估计为180 mg，而在胎粪中发现的BCFA的总质量估计为16 mg，因此大多数BCFA从胎儿肠道中消失。胎粪和胎粪的BCFA谱表明，BCFA是正常健康足月新生儿胃肠道的主要成分。BCFA是在肠道定植中发挥作用的候选药物，应被视为胎儿/新生儿的营养成分。
Vernix suspended in amniotic fluid is normally swallowed by the late term fetus. We hypothesized that branched chain fatty acids (BCFA), long known to be major vernix components, would be found in meconium and that the profiles would differ systematically. Vernix and meconium were collected from term newborns and analyzed. BCFA-containing lipids constituted about 12% of vernix dry weight, and were predominantly saturated, and had 11 to 26 carbons per BCFA. In contrast, meconium BCFA had 16 to 26 carbons, and was about 1% of dry weight. Meconium BCFA were mostly in the iso configuration, whereas vernix BCFA contained dimethyl and middle chain branching, and five anteiso BCFA. The mass of BCFA entering the fetal gut as swallowed vernix particles is estimated to be 180 mg in the last month of gestation while the total mass of BCFA found in meconium is estimated to be 16 mg, thus most BCFA disappear from the fetal gut. The BCFA profiles of vernix and meconium show that BCFA are major components of normal healthy term newborn gastrointestinal tract. BCFA are candidates for agents that play a role in gut colonization and should be considered a nutritional component for the fetus/newborn.