Preventive effect of iganidipine on renal and cerebral injuries in salt-induced hypertension.
Preventive effect of iganidipine on renal and cerebral injuries in salt-induced hypertension.
复制标题
伊甘地平对盐性高血压肾脑损伤的预防作用。
DOI：
10.1016/s0895-7061(97)00094-0
复制
发表时间：
1997
影响因子：
3.2
通讯作者：
A. Ichikawa
中科院分区：
文献类型：
--
作者：
H. Shirahase;K. Wada;Y. Uehara;S. Nakamura;A. Ichikawa
Iganidipine, a new water-soluble calcium antagonist, was administered at a nonhypotensive dose (NHD) of 0.3 mg/kg/day, a moderate-hypotensive dose (MHD) of 1.0 mg/kg/day, and a sustained-hypotensive dose (SHD) of 3.0 mg/kg/day to Dahl salt-sensitive (Dahl-S) rats fed a high-salt diet for 8 weeks. The effects on survival, and on renal and cerebral injuries, were then examined. Iganidipine completely prevented hypertensive death at the SHD and tended to increase the survival at the NHD and MHD. Iganidipine reduced glomerulosclerosis and renal arterial and tubular injuries in a dose-dependent manner. Iganidipine at the SHD, but not NHD or MHD, improved plasma creatinine, serum urea nitrogen, and glomerular filtration rate. Iganidipine at all doses examined increased the urinary prostaglandin (PG) I2and PGE2, but not PGF2αor thromboxane B2, and decreased plasma angiotensin II (AII) level and renin activity. The renal glomerular, tubular, and arterial injuries were significantly correlated with blood pressure (r = 0.56 to 0.80) and plasma AII level (r = 0.50 to 0.71) but not with urinary prostanoids. Iganidipine also reduced the incidence of cerebral infarction. The infarction area was slightly and significantly correlated with urinary PGI2(r = 0.42) and PGE2(r = 0.41) but not with blood pressure or plasma AII. In conclusion, iganidipine prevented renal and cerebral injuries in Dahl-S rats. In addition to the reduced blood pressure, the reduction of plasma AII and the increase of vasodilatory prostanoids may also partially contribute to the renal and cerebral protective effects of iganidipine.Am J Hypertens 1997;10:869–878
血管紧张素 II 受体拮抗剂可延缓盐负荷 Dahl 盐敏感大鼠的肾损伤和中风。
影响因子：
4.9
作者：
vonLutterotti,N;Camargo,MJ;CampbellJr,WG;Mueller,FB;Timmermans,PB;Sealey,JE;Laragh,JH
通讯作者：
Laragh,JH
影响因子：
19.6
作者：
GRIFFIN, KA;PICKEN, M;BIDANI, AK
通讯作者：
BIDANI, AK
高钙血症肾病：以髓质内条纹损伤为主的慢性疾病。
影响因子：
19.6
作者：
Rosen,S;Greenfeld,Z;Bernheim,J;Rathaus,M;Podjarny,E;Brezis,M
通讯作者：
Brezis,M