Alcohol intake, drinking patterns, and risk of nonfatal acute myocardial infarction in Costa Rica
Alcohol intake, drinking patterns, and risk of nonfatal acute myocardial infarction in Costa Rica
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DOI：
10.1093/ajcn/82.6.1336
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发表时间：
2005-12-01
影响因子：
7.1
通讯作者：
Campos, H
中科院分区：
文献类型：
--
作者：
Kabagambe, EK;Baylin, A;Campos, H
背景：适度饮酒与较低的心肌梗死(MI)风险相关。酒精是否真的具有保护作用，或者酒精的摄入量、类型或模式是否是最重要的，目前仍存在争议。目的：本研究的目的是确定酒精摄入量和饮酒模式是否与哥斯达黎加人的血脂和心肌梗死风险有关。哥斯达黎加是一个饮食和生活方式与西方国家不同的国家，设计：我们对2090例首例非致命性急性心肌梗死病例和2090例以年龄、性别和居住为基础的人群对照进行了研究。结果：在控制其他心血管疾病危险因素的多因素条件回归模型中，平均饮酒3次/周(与终生不饮酒者相比)的MI风险最低[优势比(OR)=0.44；95%可信区间0.31，0.61]。当我们观察饮酒频率时，我们发现，无论饮酒量如何，日常饮酒者与周末饮酒者发生MI的风险(OR=0.64；95%CL 0.41，1.01)没有显著差异(P=0.23)。高密度脂蛋白胆固醇随着饮酒量和饮酒频率的增加而增加。与其他一些人群相似，在酒精摄入量很低的情况下观察到了明显的保护作用。结论：低至中等饮酒量1-2d/wk与MI风险的降低独立相关。
Background: Moderate alcohol consumption is associated with a lower risk of myocardial infarction (MI). Whether alcohol is truly protective or whether the amount, type, or pattern of intake is the most important is still under debate.Objective: The purpose of this study was to determine whether alcohol intake and drinking patterns are associated with plasma lipids and the risk of MI in Costa Ricans, a population with a low intake of wine.Design: We conducted a study of 2090 cases of a first nonfatal acute MI and 2090 population-based controls matched by age, sex, and residence in Costa Rica, a country with diet and lifestyles different from those of Western countries. Alcohol and dietary intakes were assessed by using validated questionnaires.Results: In a multivariate conditional regression model that controlled for other cardiovascular disease risk factors, the lowest risk of MI [odds ratio (OR) = 0.44; 95% CI 0.31, 0.61] was observed for those who drank on average 3 drinks/wk (compared with lifelong abstainers). When we looked at the frequency of consumption, we found that the risk of MI among daily drinkers (OR = 0.64; 95% CL 0.41, 1.01) was not significantly different (P = 0.23) from that of weekend drinkers (OR = 0.76; 95% CI: 0.59,0.98) regardless of the amount consumed. HDL cholesterol increased with the amount and frequency of alcohol intake. Similar to a few other populations, apparent protection was observed at very low alcohol intakes.Conclusion: Low to moderate consumption of alcohol 1-2 d/wk is independently associated with a reduced risk of MI.