WOOD-RELATED OCCUPATIONS, WOOD DUST EXPOSURE, AND SINONASAL CANCER
WOOD-RELATED OCCUPATIONS, WOOD DUST EXPOSURE, AND SINONASAL CANCER
复制标题
DOI：
10.1093/oxfordjournals.aje.a114429
复制
发表时间：
1986-10-01
影响因子：
5
通讯作者：
DEBRUYN, A
中科院分区：
文献类型：
--
作者：
HAYES, RB;GERIN, M;DEBRUYN, A
进行了一项病例对照研究，以检验木工类型和木尘暴露程度与特定组织学类型鼻咽癌的风险之间的关系。与荷兰的主要治疗中心合作，确定了在1978至1981年间新诊断的116名男性患者，他们患有该部位的原发上皮性恶性肿瘤。生活对照是从市政登记中选择的，死亡对照是从国家死亡登记中选择的。91名患者(78%)和195名对照(75%)完成了访谈。工作历史是按行业和职业编码的。制定了一项暴露指数，对职业接触木尘的程度进行分类。必要时，会根据年龄和平时吸烟情况进行调整。木材和造纸业的职业(OR=11.9)、家具和家具制造行业的职业(OR=139.8)、工厂的细木工和木工(OR=16.3)、高水平的木尘暴露(OR=26.3)是鼻腺癌的高危因素。其他类型的鼻癌没有被发现与木材相关的行业或职业有关。中度过高的鳞状细胞癌风险(OR=2.5)与低水平的木尘接触有关；然而，没有明显的剂量-反应关系。在1930年至1941年间从事木尘相关职业的人中，木尘与腺癌之间的关联性最强。在停止接触木尘后至少15年内，患腺癌的风险似乎没有下降。在1941年后首次接触木尘的男性中，没有观察到鼻腺癌病例。
A case-control study was conducted to examine the relations between type of woodworking and the extent of wood dust exposure to the risks for specific histologic types of sinonasal cancer. In cooperation with the major treatment centers in the Netherlands, 116 male patients newly diagnosed between 1978 and 1981 with primary malignancies of epithelial origin of this site were identified for study. Living controls were selected from the municipal registries, and deceased controls were selected from the national death registry. Interviews were completed for 91 (78%) cases and 195 (75%) controls. Job histories were coded by industry and occupation. An index of exposure was developed to classify the extent of occupational exposure to wood dust. When necessary, adjustment was made for age and usual cigarette use. The risk for nasal adenocarcinoma was elevated by industry for the wood and paper industry (odds ratio (OR) = 11.9) and by occupation for those employed in furniture and cabinet making (OR = 139.8), in factory joinery and carpentry work (OR = 16.3), and in association with high-level wood dust exposure (OR = 26.3). Other types of nasal cancer were not found to be associated with wood-related industries or occupations. A moderate excess in risk for squamous cell cancer (OR = 2.5) was associated with low-level wood dust exposure; however, no dose-response relation was evident. The association between wood dust and adenocarcinoma was strongest for those employed in wood dust-related occupations between 1930 and 1941. The risk of adenocarcinoma did not appear to decrease for at least 15 years after termination of exposure to wood dust. No cases of nasal adenocarcinoma were observed in men whose first exposure to wood dust occurred after 1941.