Multicomponent reactions are accelerated in water
Multicomponent reactions are accelerated in water
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DOI：
10.1021/ja038583a
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发表时间：
2004-01-21
影响因子：
15
通讯作者：
Das Sarma, K
中科院分区：
文献类型：
--
作者：
Pirrung, MC;Das Sarma, K
两个多组分反应，Ugi和Passerini反应，通过使用水溶液来加速。与有机溶剂相比，速率提高可接近300倍。在水中进行的反应提供了另一个优点，即产物通常是不溶的，允许通过沉淀直接分离。将该方法应用于三个小的组合文库的制备。
Two multicomponent reactions, the Ugi and Passerini reactions, are accelerated by the use of aqueous solutions. The rate enhancements compared to those by organic solvents can approach 300-fold. Reactions performed in water offer another advantage that products are often insoluble, permitting direct isolation by precipitation. The methods were applied to the preparation of three small combinatorial libraries.