Study on controlled drug permeation of magnetic-sensitive ferrogels:: Effect of Fe3O4 and PVA
Study on controlled drug permeation of magnetic-sensitive ferrogels:: Effect of Fe3O4 and PVA
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DOI：
10.1016/j.jconrel.2007.12.006
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发表时间：
2008-03-20
影响因子：
10.8
通讯作者：
Chen, San-Yuan
中科院分区：
文献类型：
--
作者：
Liu, Ting-Yu;Hu, Shang-Hsiu;Chen, San-Yuan
采用冻融法进行物理交联，制备了PVA基磁敏水凝胶(铁凝胶)。从磁导率系数(P)、分配系数(H)、空间限制和磁化强度等方面系统地研究了组成成分Fe3O4和PVA对铁氧体磁敏行为的影响。结果表明，在磁场作用下，铁氧体中的P值减小，并表现出一种磁敏特性，这与H值的变化有关。此外，研究还发现，虽然空间限制或磁化强度对磁敏行为有相反的影响，但当Fe3O4和PVA的最佳组成为17-34%和10-12.5%时，铁氧体具有较好的磁敏行为，并且从每纳米颗粒的有效自由体积(V-Free)和磁化强度这两个临界参数来看，可以很好地与理论计算相关联。绘制了磁敏行为图，其中观察到了一个相对稳定的、与FC3O4浓度有关的高度刺激响应行为的区域，然而，在“饱和”区域(17-34%Fe3O4)以下或之上，检测到磁敏感行为的降低。由此产生的铁氧体可以设计成精确控制孔结构的打开和关闭，从而允许从外部和磁性控制治疗活性物质的突然释放或不释放行为。这表明这种类型的铁凝胶可以被认为是一类新型的磁性可调谐药物释放系统。(C)2007 Elsevier B.V.保留所有权利。
A PVA-based magnetic-sensitive hydrogel (ferrogel) was fabricated by physical cross-linking through a freezing-thawing method. The influence of the constituting components, i.e., Fe3O4 and PVA, on the magnetic-sensitive behavior of the ferrogels was systematically investigated in terms of permeability coefficient (P), partition coefficient (H), space restriction and magnetization. The results show that, the P value in these ferrogels decreases and displays a magnetic sensitivity when it is subjected to magnetic field (MF), which is correlated with the change of H value. In addition, it was found that although the factor of space restriction or magnetization exerts opposite effect on resulting magnetic-sensitive behavior, the superior magnetic-sensitive behavior was observed for the ferrogels with an optimal composition of 17-34% Fe3O4 and 10-12.5% PVA, and can be well correlated with theoretical calculation from the critical parameters of available free volume per nanoparticle (V-free) and magnetization. A map of magnetic-sensitive behavior was constructed, where a region with relatively stable and highly stimuli-responsive behavior in terms of the concentration of FC3O4 was observed, however, below or above the "saturation" region (17-34% Fe3O4), a reduction in the magnetic-sensitive behavior was detected. The resulting ferrogels can be engineered with a precise control of the opening and closure of pore configuration, which allows a burst release or no-release action of therapeutically active agent to be controlled externally and magnetically. This suggests that this type of ferrogel can be considered as a class of novel magnetically-tunable drug delivery system. (c) 2007 Elsevier B.V. All rights reserved.