Sex differences in stroke survival: 10-year follow-up of the Copenhagen stroke study cohort.
Sex differences in stroke survival: 10-year follow-up of the Copenhagen stroke study cohort.
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DOI：
10.1016/j.jstrokecerebrovasdis.2005.06.002
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发表时间：
2005-09-01
期刊：
影响因子：
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通讯作者：
Olsen, Tom Skyhoj
中科院分区：
文献类型：
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作者：
Andersen, Morten Nonboe;Andersen, Klaus Kaae;Olsen, Tom Skyhoj
背景技术背景：虽然有分歧，大多数研究表明，性别对中风survival.METHODS没有显着影响：在哥本哈根，丹麦，社区所有中风患者在1992年3月至1993年11月登记入院。使用斯堪的纳维亚卒中量表（0-58）测量卒中严重程度;计算机断层扫描确定卒中类型。获得所有患者的危险因素概况，包括缺血性心脏病、高血压、糖尿病、房颤、既往卒中、吸烟和饮酒。在10年随访期内获得死亡日期。死亡的预测因素采用考克斯比例风险model.Results：999例患者中，559例（56%）为女性，440例（44%）为男性。女性年龄更大（77.0 v70.9岁; P < .001），中风更严重（斯堪的纳维亚中风量表：36.1 v40.5; P < .001）。性别间缺血性心脏病、高血压、房颤、糖尿病和既往卒中的危险因素无差异。男性更多的时候是吸烟者和饮酒者。男性和女性的未调整生存率没有差异：分别为70.3%和66.7%（1年）、40.0%和38.9%（5年）、17.4%和18.7%（10年）。校正年龄、中风严重程度、中风类型和危险因素后，女性患者1年生存率较高（风险比1.47，95%置信区间1.10-2.00）; 5年（风险比1.47，95%置信区间1.23-1.76）;和10年（风险比1.49，95%置信区间1.28-1.76）。卒中后9个月前，存活率无差异。中风的严重程度对性别有相同的影响。结论：中风在男性和女性中同样严重。短期生存是一样的。然而，在中风中幸存下来的女性寿命更长。
BACKGROUND: Although diverging, most studies show that sex has no significant influence on stroke survival.METHODS: In a Copenhagen, Denmark, community all patients with stroke during March 1992 to November 1993 were registered on hospital admission. Stroke severity was measured using the Scandinavian Stroke Scale (0-58); computed tomography determined stroke type. A risk factor profile was obtained for all including ischemic heart disease, hypertension, diabetes mellitus, atrial fibrillation, previous stroke, smoking, and alcohol consumption. Date of death was obtained within a 10-year follow-up period. Predictors of death were identified using a Cox proportional hazards model.RESULTS: Of 999 patients, 559 (56%) were women and 440 (44%) were men. Women were older (77.0 v 70.9 years; P < .001) and had more severe strokes (Scandinavian Stroke Scale: 36.1 v 40.5; P < .001). Age-adjusted risk factors showed no difference between sexes for ischemic heart disease, hypertension, atrial fibrillation, diabetes mellitus, and previous stroke. Men more often were smokers and alcohol consumers. Unadjusted survival in men and women did not differ: 70.3% versus 66.7% (1-year), 40.0% versus 38.9% (5-year), and 17.4% versus 18.7% (10-year), respectively. Adjusting for age, stroke severity, stroke type, and risk factors, women had a higher probability of survival at 1 year (hazard ratio 1.47, 95% confidence interval 1.10-2.00); 5 years (hazard ratio 1.47, 95% confidence interval 1.23-1.76); and 10 years (hazard ratio 1.49, 95% confidence interval 1.28-1.76). Before 9 months poststroke, no difference in survival was seen. Severity of stroke had the same effect on sex.CONCLUSION: Stroke is equally severe in men and women. Short-term survival is the same. Having survived stroke, women, however, live longer.