Multiple intrahepatic biliary cysts in children with biliary atresia.
Multiple intrahepatic biliary cysts in children with biliary atresia.
复制标题
胆道闭锁儿童的多发性肝内胆管囊肿。
DOI：
10.1053/jpsu.2002.34468
复制
发表时间：
2002
影响因子：
2.4
通讯作者：
Mei‐Hwei Chang
中科院分区：
文献类型：
--
作者：
L. Bu;Huey‐Ling Chen;Y. Ni;S. Peng;Y. Jeng;H. Lai;Mei‐Hwei Chang
目的
本研究的目的是探讨胆道闭锁患者多发性肝内胆管囊肿的发病率、临床病程和预后。
方法
1992 ~ 2000年，对154例胆道闭锁患者进行肝内囊肿检查。他们被跟踪和检查常规腹部超声检查。
结果
单发囊肿23例，多发囊肿16例。各种类型肝内囊肿的发生率为25.3%（39/154），多发性肝内囊肿的发生率为10.4%（16/154）。16例多发性囊肿中，13例（81.3%）有黄疸，15例（93.8%）有胆管炎病史。影像学检查显示多个离散的卵圆形或圆形肝内胆管囊肿，大小不一，沿着胆管树分布。抗生素治疗后，7例患者的囊肿大小或数量减少，仅1例患者消失。多囊肿患者的死亡率高于单囊肿患者（P = 0.037）。
结论
多发性肝内胆管囊肿是胆道闭锁患者常见的并发症，预后不良。当出现胆道感染的迹象时，应给予延长的肠外抗生素治疗。
PURPOSE
The aim of this study was to investigate the incidence, clinical course, and outcome of multiple intrahepatic biliary cysts in patients with biliary atresia.
METHODS
From 1992 to 2000, 154 patients with biliary atresia were examined for intrahepatic cysts. They were followed and examined routinely using abdominal ultrasonography.
RESULTS
Twenty-three patients had single intrahepatic cysts, and 16 patients had multiple cysts. The incidence of intrahepatic cysts in these patients were 25.3% (39 of 154) for all kinds of cysts and 10.4% (16 of 154) for multiple intrahepatic cysts. Of the 16 patients with multiple cysts, 13 (81.3%) had jaundice, and 15 (93.8%) had a history of cholangitis before cysts were detected. Image studies showed multiple discrete ovoid or round intrahepatic biliary cysts with various sizes along the biliary trees. The cysts decreased in size or number in 7 patients after antibiotic treatment and disappeared in only one patient. The mortality rate was higher in patients with multiple cysts than in those with single cysts (P =.037).
CONCLUSIONS
Multiple intrahepatic biliary cysts are a common complication in patients with biliary atresia and suggests a poor prognosis. Prolonged parenteral antibiotics treatment should be administered when signs of biliary infection appear.