Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients
Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients
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DOI：
10.1007/s12032-011-9821-3
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发表时间：
2012-06-01
期刊：
影响因子：
3.4
通讯作者：
Aktan, Melih
中科院分区：
文献类型：
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作者：
Hancer, Veysel Sabri;Diz-Kucukkaya, Reyhan;Aktan, Melih
Rai和Binet分期系统已被用作评估慢性淋巴细胞白血病（CLL）预后的标准方法，在区分早期CLL患者时存在一定的局限性，这些患者将迅速进展。为了解决这一缺点，近年来，分期以外的预后参数变得重要。CLL患者白血病淋巴细胞内Fc μ受体（FCMR，FAIM 3/TOSO）基因表达上调可能是预测疾病进展的重要指标。在这项研究中，FCMR mRNA表达水平进行了评估，在50例CLL患者和50名健康对照。FCMR mRNA表达在CLL患者中显著高于健康对照。然后，我们根据CLL的阶段评估FCMR mRNA水平。根据FCMR mRNA水平将Rai 0、I、II期病例与III、IV期病例进行比较，并将Binet A与Binet B和C进行比较。在具有较高风险的病例中，Rai III、IV期和Binet B和C期，FCMR mRNA水平也显著较高。此外，FCMR的过度表达似乎促进了染色体异常。结果发现，慢性淋巴细胞白血病患者中FCMR的mRNA水平是对照组的23倍，这可能表明它可能与疾病进展和生存有关。由于这个原因，并且由于Q-PCR分析的简单性，它可以是一个有用的临床参数，在它的重要性已经在更大的和多变量的研究中显示出来。
Rai and Binet staging systems that have been used as a standard method for evaluating the prognosis of chronic lymphocytic leukemia (CLL) have some restrictions in distinguishing the early stage CLL patients that will progress rapidly. To solve this shortcoming, prognostic parameters other than staging have become important in the recent years. Intracellular upregulation of Fc mu receptor (FCMR, FAIM3/TOSO) gene in the leukemic lymphocytes of the patients with CLL may be an important parameter in predicting the progression of the disease. In this study, FCMR mRNA expression levels were evaluated in 50 CLL patients and in 50 healthy controls. FCMR mRNA expression was found to be significantly higher in CLL patients than in healthy controls. We, then, evaluated FCMR mRNA levels according to the stages of CLL. Rai stage 0, I, II cases were compared with stage III and IV, and Binet A was compared with Binet B and C according to FCMR mRNA levels. In cases with higher risks, Rai stage III, IV and Binet stage B and C, FCMR mRNA levels were also significantly higher. In addition, overexpression of the FCMR seems to be promoting the chromosomal abnormalities. As a result, we found that the mRNA levels of FCMR in the CLL patients are 23-fold higher than that of the control group and this may suggest that it can be associated with the disease progression and survival. For this reason and because of the simplicity of analyzing with Q-PCR, it can be a useful clinical parameter, after its importance has been shown in larger and multi-variate studies.