Efficacy data of halogenated phenazine and quinoline agents and an NH125 analogue to veterinary mycoplasmas
Efficacy data of halogenated phenazine and quinoline agents and an NH125 analogue to veterinary mycoplasmas
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DOI：
10.1186/s12917-020-02324-4
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发表时间：
2020-04-06
影响因子：
2.6
通讯作者：
Brown, Mary B.
中科院分区：
文献类型：
--
作者：
Valentine-King, Marissa A.;Cisneros, Katherine;Brown, Mary B.
支原体主要引起呼吸道或泌尿生殖道感染，影响禽类、牛、犬、山羊、鼠和爬行动物宿主。在畜牧业中，支原体导致饲料转化率降低，产蛋量减少，关节炎，缺乳或无乳，增加繁殖，淘汰，在某些情况下死亡。抗生素可减少传播并减轻临床症状;然而，考虑到鸡毒支原体和支原体的抗生素耐药性水平，存在摩羯分离物。为了解决这些问题，我们通过微肉汤或琼脂稀释法评估了卤代吩嗪和喹啉化合物、N-芳基化NH 125类似物和三氯生对六种代表性兽用支原体的最低抑菌浓度（MIC）。此后，我们评估了有效药物的最低杀菌浓度（MBC）。结果鉴定了几种具有MIC值的化合物
Background Mycoplasmas primarily cause respiratory or urogenital tract infections impacting avian, bovine, canine, caprine, murine, and reptilian hosts. In animal husbandry, mycoplasmas cause reduced feed-conversion, decreased egg production, arthritis, hypogalactia or agalactia, increased condemnations, culling, and mortality in some cases. Antibiotics reduce transmission and mitigate clinical signs; however, concerning levels of antibiotic resistance in Mycoplasma gallisepticum and M. capricolum isolates exist. To address these issues, we evaluated the minimum inhibitory concentrations (MICs) of halogenated phenazine and quinoline compounds, an N-arylated NH125 analogue, and triclosan against six representative veterinary mycoplasmas via microbroth or agar dilution methods. Thereafter, we evaluated the minimum bactericidal concentration (MBC) of efficacious drugs. Results We identified several compounds with MICs