EFFECTS OF BLOOD-TRANSFUSION ON EXERCISE CAPACITY IN PATIENTS WITH SICKLE-CELL-ANEMIA
EFFECTS OF BLOOD-TRANSFUSION ON EXERCISE CAPACITY IN PATIENTS WITH SICKLE-CELL-ANEMIA
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DOI：
10.1016/0002-9343(83)91063-x
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发表时间：
1983-01-01
影响因子：
5.9
通讯作者：
BROSS, DS
中科院分区：
文献类型：
--
作者：
CHARACHE, S;BLEECKER, ER;BROSS, DS
尽管镰状细胞的细胞内粘度增加，但患者血液的粘度通常不会增加，因为此类患者通常发现血细胞比容低。当患者接受输血时，他们的运动能力会增加，但尚不清楚这种变化是否主要是由于血红蛋白浓度增加，或者也反映了由于镰状细胞被正常红细胞稀释而导致的血液流动特性的改善。为了评估这两个因素的相对重要性，在一系列输血之前和之后进行了次最大运动研究。运动能力得到改善，患者能够以较低的心率完成更多的工作量。回归分析表明，考虑到输血引起的血红蛋白浓度增加后，患者血液中镰状细胞的百分比对运动能力没有显着影响。在患者中通常发现的血细胞比容中，由于镰状细胞的存在而导致的血液粘度变化作为运动能力的决定因素远不如血红蛋白浓度那么重要。
Although sickle cells have increased intracellular viscosity, the viscosity of patient''s blood is usually not increased, because of the low hematocrit typically found in such patients. When patients receive transfusions, their exercise capacity increases, but it is unclear whether the change is due primarily to increased Hb concentration, or also reflects improved flow properties of the blood due to dilution of sickle cells with normal erythrocytes. To evaluate the relative importance of these 2 factors, submaximal exercise studies were performed before and after a series of transfusions. Exercise capacity improved and the patients were able to perform increased amounts of work at lower heart rates. Regression analyses indicated that the percent of sickle cells in patient''s blood did not have a significant effect on exercise capacity after the transfusion-induced increase in Hb concentration was taken into account. At the hematocrits typically found in patients, altered viscosity of blood due to the presence of sickle cells is much less important than Hb concentration as a determinant of exercise capacity.