The relationship between hippocampal volume, chronic pain, and depressive symptoms in older adults
The relationship between hippocampal volume, chronic pain, and depressive symptoms in older adults
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DOI：
10.1016/j.pscychresns.2019.05.003
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发表时间：
2019-07-30
影响因子：
2.3
通讯作者：
Lipton, Richard B.
中科院分区：
文献类型：
--
作者：
Ezzati, Ali;Zammit, Andrea R.;Lipton, Richard B.
我们的目的是检验慢性疼痛对抑郁症状的影响是通过海马体积（HV）介导的这一假设。参与者是来自爱因斯坦衰老研究的131名70岁以上的非痴呆成年人。较小的右侧和左侧HV均与较高的抑郁症状相关，但只有较小的右侧HV与慢性疼痛相关。在中介模型中，右HV是慢性疼痛对抑郁影响的重要中介。我们的研究结果表明，慢性疼痛和抑郁症之间存在共享的大脑基质，反映了右HV。
We aimed to test the hypothesis that the effect of chronic pain on depressive symptoms is mediated through hippocampal volume (HV). Participants were 131 non-demented adults over the age of 70 years from the Einstein Aging Study. Smaller right and left HV were both associated with higher depressive symptoms, but only smaller right HV was associated with chronic pain. In mediation models, right HV was a significant mediator for the effect of chronic pain on depression. Our findings suggest presence of a shared brain substrates between chronic pain and depression as reflected by right HV.