Beneficial effects of a Dietary Approaches to Stop Hypertension eating plan on features of the metabolic syndrome
Beneficial effects of a Dietary Approaches to Stop Hypertension eating plan on features of the metabolic syndrome
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DOI：
10.2337/diacare.28.12.2823
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发表时间：
2005-12-01
期刊：
影响因子：
16.2
通讯作者：
Azizi, F
中科院分区：
文献类型：
--
作者：
Azadbakht, L;Mirmiran, P;Azizi, F
目的 - 确定膳食控制高血压 (DASH) 饮食计划对代谢综合征患者代谢风险的影响。 研究设计和方法 - 这是一项对 116 名代谢综合征患者进行的随机对照全科患者试验。为期 6 个月的处方规定了三种饮食：对照饮食、强调健康食物选择的减肥饮食、以及减少热量并增加水果、蔬菜、低脂乳制品和全谷物摄入量、降低饱和脂肪、总脂肪和胆固醇并限制在 2,400 毫克钠的 DASH 饮食。主要结果指标是代谢综合征的组成部分。 结果 - 相对于对照饮食，DASH 饮食导致较高的 HDL 胆固醇（7 和 10 毫克/分升）、较低的甘油三酯（- 18 和 - 14 毫克/分升）、收缩压 (SBP)（- 12 和 -11 毫米汞柱）、舒张压（- 6 和 - 7 毫米汞柱）、体重（- 16 男性和女性的体重分别为（- 16 和 - 14 kg）、空腹血糖（FBG）（- 15 和 -8 mg/dl）（所有 P < 0.001）。男性和女性的甘油三酯（- 17 和 - 18 mg/dl）、收缩压（-11 和 -11 mmHg）、舒张压（- 5 和 - 6 mmHg）、FBG（- 4 和 - 6 mg/dl）、体重（- 16 和 - 15 kg）以及 HDL 增加（5 和 10 mg/dl）的净减少量分别较高， DASH 组（所有 P < 0.05）。减肥饮食导致男性和女性的甘油三酯（-13 和 -10 mg/dl）、收缩压（- 6 和 - 6 mmHg）以及体重（- 13 和 - 12 kg）分别发生显着变化（所有 P < 0.05）。结论 - DASH 饮食可能可以降低男性和女性的大部分代谢风险；相关机制有待进一步研究。
OBJECTIVE - To determine the effects of a Dietary Approaches to Stop Hypertension (DASH) eating plan on metabolic risks in patients with the metabolic syndrome.RESEARCH DESIGN AND METHODS - This was a randomized controlled ompatient trial conducted on 116 patients with the metabolic syndrome. Three diets were prescribed for 6 months: a control diet, a weight-reducing diet emphasizing healthy food choices, and the DASH diet with reduced calories and increased consumption of fruit, vegetables, low-fat dairy, and whole grains and lower in saturated fat, total fat, and cholesterol and restricted to 2,400 mg Na. The main outcome measures were the components of the metabolic syndrome.RESULTS - Relative to the control diet, the DASH diet resulted in higher HDL cholesterol (7 and 10 mg/dl), lower triglycerides (- 18 and - 14 mg/dl), systolic blood pressure (SBP) (- 12 and -11 mmHg), diastolic blood pressure (- 6 and - 7 mmHg), weight (- 16 and - 14 kg), fasting blood glucose (FBG) (- 15 and -8 mg/dl), and weight (- 16 and - 15 kg), among men and women, respectively (all P < 0.001). The net reduction in triglycerides (- 17 and - 18 mg/dl), SBP (-11 and -11 mmHg), diastolic blood pressure (- 5 and - 6 mmHg), and FBG (- 4 and - 6 mg/dl), weight (- 16 and - 15 kg), and increase in HDL (5 and 10 mg/dl) among men and women, respectively, was higher in the DASH group (all P < 0.05). The weight-reducing diet resulted in significant change in triglycerides (-13 and -10 mg/dl), SBP (- 6 and - 6 mmHg), and weight (- 13 and - 12 kg) among men and women, respectively (all P < 0.05).CONCLUSIONS - The DASH diet can likely reduce most of the metabolic risks in both men and women; the related mechanisms need further study.