Neural correlates of emotion regulation deficits in remitted depression: The influence of regulation strategy, habitual regulation use, and emotional valence
Neural correlates of emotion regulation deficits in remitted depression: The influence of regulation strategy, habitual regulation use, and emotional valence
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DOI：
10.1016/j.neuroimage.2012.03.089
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发表时间：
2012-07-02
期刊：
影响因子：
5.7
通讯作者：
Wessa, Michele
中科院分区：
文献类型：
--
作者：
Kanske, Philipp;Heissler, Janine;Wessa, Michele
通过重新评价来调节情绪已被证明会引起当前抑郁症患者的异常神经激活模式。然而，目前尚不清楚这种缺陷是否普遍适用于其他情绪调节策略，当患者恢复时是否仍然存在，以及是否与习惯性使用重新评价策略有关。因此，我们用功能磁共振成像测量了有抑郁症病史的缓解期患者和健康对照者对情绪图像的神经反应。在观看图像时，参与者使用重新评价或分散注意力策略来调节所引发的情绪。采用认知情绪调节问卷测量习惯性再评价的使用情况。抑郁症患者表现出选择性缺陷，在下调杏仁核反应的负面情绪刺激使用重新评价。这种杏仁核活动的下调在习惯性重新评价使用率高的参与者中最为强烈。在两种情绪调节策略中，包括前扣带回和外侧眶额皮层在内的调节控制网络的活动都增加了。在有抑郁症病史的缓解期患者中的研究结果表明，改变的情绪调节是抑郁症的一个特征标记。这一解释得到了习惯性重评使用与杏仁核下调成功的关系的支持。(c)2012 Elsevier Inc. All rights reserved.
Regulating emotions through reappraisal has been shown to elicit abnormal neural activation patterns in currently depressed patients. It is, however, unclear if this deficit generalizes to other emotion regulation strategies, if it persists when patients recover, and if it is related to habitual use of reappraisal strategies. Therefore, we measured the neural responses to emotional images with functional magnetic resonance imaging in remitted patients with previous episodes of major depression and healthy controls. While viewing the images participants regulated the elicited emotions using either a reappraisal or a distraction strategy. Habitual reappraisal use was measured with the Cognitive Emotion Regulation Questionnaire. Depressed patients showed a selective deficit in down-regulating amygdala responses to negative emotional stimuli using reappraisal. This down-regulation of amygdala activity was strongest in participants high in habitual reappraisal use. Activity in the regulating control-network including anterior cingulate and lateral orbitofrontal cortex was increased during both emotion regulation strategies. The findings in remitted patients with previous episodes of major depression suggest that altered emotion regulation is a trait-marker for depression. This interpretation is supported by the relation of habitual reappraisal use to amygdala down-regulation success. (c) 2012 Elsevier Inc. All rights reserved.