Detecting Molecular Fingerprints in Single Molecule Force Spectroscopy Using Pattern Recognition

Detecting Molecular Fingerprints in Single Molecule Force Spectroscopy Using Pattern Recognition
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使用模式识别在单分子力谱中检测分子指纹

DOI:
10.1143/jjap.46.5540
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发表时间:
2007
影响因子:
1.5
通讯作者:
M. Rief
M. Rief
中科院分区:
物理与天体物理4区
文献类型:
--
作者:
Hendrik Dietz;M. Rief

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单分子力谱为研究蛋白质分子的力学性质提供了实验途径。通常,由于丰富的表面和多分子相互作用,只有不到1%的实验记录反映了真实的单分子事件。因此,单分子力谱中的一个关键问题是在噪声数据集中识别特定蛋白质的特征机械“指纹”。在这里,我们提出了一种客观的模式识别算法,能够在这样的噪声数据集中识别指纹。
Single molecule force spectroscopy has given experimental access to the mechanical properties of protein molecules. Typically, less than 1% of the experimental recordings reflect true single molecule events due to abundant surface and multiple-molecule interactions. A key issue in single molecule force spectroscopy is thus to identify the characteristic mechanical “fingerprint” of a specific protein in noisy data sets. Here, we present an objective pattern recognition algorithm that is able to identify fingerprints in such noisy data sets.
DOI: 10.1073/pnas.97.1.139
发表时间: 2000-01-04
影响因子: 11.1
作者:
Yang, GL;Cecconi, C;Bustamante, C
通讯作者: Bustamante, C