The role of the gastrointestinal microbiome in Helicobacter pylori pathogenesis
The role of the gastrointestinal microbiome in Helicobacter pylori pathogenesis
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DOI：
10.4161/gmic.26205
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发表时间：
2013-01-01
期刊：
影响因子：
12.2
通讯作者：
Fox, James G.
中科院分区：
文献类型：
--
作者：
Sheh, Alexander;Fox, James G.
幽门螺杆菌的发现推翻了传统的教条，即胃是一个无菌的器官，pH值<4能够使胃消毒。H.幽门螺杆菌是与胃炎、低氯血症、十二指肠溃疡和胃癌有关的病原体。现在认识到，人胃支持可能具有影响胃内稳态的数百种细菌物种的细菌群落。其他在胃中定植的细菌也可能影响H。幽门相关的胃的发病机制，通过创造活性氧和氮物种和调节炎症反应。在这篇综述中，我们总结了有关人类，小鼠和蒙古沙鼠的胃微生物群的现有文献。我们还讨论了胃扰动，许多涉及H。幽门螺杆菌，其促进来自胃肠道的其他隔室的细菌的定殖，并鉴定已知影响胃内稳态的风险因素，所述风险因素有助于微生物群的变化。
The discovery of Helicobacter pylori overturned the conventional dogma that the stomach was a sterile organ and that pH values < 4 were capable of sterilizing the stomach. H. pylori are an etiological agent associated with gastritis, hypochlorhydria, duodenal ulcers, and gastric cancer. It is now appreciated that the human stomach supports a bacterial community with possibly 100s of bacterial species that influence stomach homeostasis. Other bacteria colonizing the stomach may also influence H. pylori-associated gastric pathogenesis by creating reactive oxygen and nitrogen species and modulating inflammatory responses. In this review, we summarize the available literature concerning the gastric microbiota in humans, mice, and Mongolian gerbils. We also discuss the gastric perturbations, many involving H. pylori, that facilitate the colonization by bacteria from other compartments of the gastrointestinal tract, and identify risk factors known to affect gastric homeostasis that contribute to changes in the microbiota.