Effect of exercise and food restriction on selected markers of the acute phase response in hamsters.
Effect of exercise and food restriction on selected markers of the acute phase response in hamsters.
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运动和食物限制对仓鼠急性期反应选定标志物的影响。
DOI：
10.1152/jappl.1995.78.2.458
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kluger,MJ
中科院分区：
文献类型：
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作者：
Conn,CA;Kozak,WE;Tooten,PC;Niewold,TA;Borer,KT;Kluger,MJ
急性有氧运动已被证明会引起急性期反应（APR）的生理变化，这是一种非特异性的宿主防御反应。定期唤起这些变化可能会激发免疫系统，以提高对疾病的抵抗力。由于食物匮乏与APR受损有关，因此食物限制可能会阻止这些有益的变化。我们测试的假设，自愿运动eldaman APR和食物限制修改这一反应在四组仓鼠：自由进食久坐，自由进食锻炼，食物限制久坐，食物限制锻炼。在APR过程中改变的五个变量进行了检查：核心温度，血清铁，血清白细胞介素-6，血清淀粉样蛋白A，血清糖皮质激素测定的生物遥测，比色分析，B-9细胞生长测定，间接酶联免疫吸附试验，放射免疫分析，分别。在仓鼠接触转轮19-20天后的非活动期期间抽血。运动可使静息核心温度升高，限食可使静息核心温度降低（P < 0.01）。限食可降低铁含量（P < 0.01）。限食可使皮质醇升高，但不影响皮质酮（P < 0.001）。各组间白细胞介素-6（P > 0.49）和血清淀粉样蛋白A（P > 0.29）差异无统计学意义。我们的结论是，几乎没有证据表明自愿运动或运动结合食物限制导致仓鼠的APR。
Acute aerobic exercise has been shown to elicit physiological changes characteristic of the acute phase response (APR), a nonspecific host defense response. Regular evocation of these changes may prime the immune system to improve resistance to disease. Because food deprivation is associated with an impaired APR, food restriction may prevent these beneficial changes. We tested the hypotheses that voluntary exercise elicits an APR and that food restriction modifies this response in four groups of hamsters: ad libitum-fed sedentary, ad libitum-fed exercised, food-restricted sedentary, and food-restricted exercised. Five variables altered during an APR were examined: core temperature, serum iron, serum interleukin-6, serum amyloid A, and serum glucocorticoids measured by biotelemetry, colorimetric analysis, B-9 cell growth assay, indirect enzyme-linked immunosorbent assay, and radioimmunoassay, respectively. Blood was drawn during the hamsters' inactive period after 19–20 days of access to running wheels. Resting core temperature was elevated by exercise and depressed by food restriction (P < 0.01). Iron was depressed by food restriction (P < 0.01). Cortisol, but not corticosterone, was elevated by food restriction (P < 0.001). There were no significant differences among groups in interleukin-6 (P > 0.49) or serum amyloid A (P > 0.29). We conclude that there is little evidence that voluntary exercise or exercise combined with food restriction causes an APR in hamsters.