The membrane change in En(a-) human erythrocytes. Absence of the major erythrocyte sialoglycoprotein.
The membrane change in En(a-) human erythrocytes. Absence of the major erythrocyte sialoglycoprotein.
复制标题
En(a-) 人红细胞的膜变化。
作者：
M. Tanner;D. Anstee
我们研究了En（a-）人红细胞的膜，作为哺乳动物细胞表面糖蛋白结构和生化功能研究的一部分。2. 选择En（a-）红细胞是因为它们在细胞表面的变化比任何其他已知的红细胞变体更广泛。3. 我们的结果表明，在En（a-）红细胞中：(a)主要的膜唾液糖蛋白缺乏；(b)另一个主要的穿膜糖蛋白（带3）具有改变的电泳迁移率。4. 临床表现正常的En（a-）细胞表明，第3带的变化可能弥补了膜唾液糖蛋白的缺失。很明显，一个活红细胞可以存在，尽管缺乏其主要的表面成分之一。
We investigated the membrane of En(a-) human erythrocytes as part of a study of the structure and biochemical function of the surface glycoproteins of the mammalian cell. 2. En(a-) erythrocytes were selected because they have more extensive changes at the cell surface than any other known erythrocyte variant. 3. Our results show that in En(a-) erythrocytes: (a) the major membrane sialoglycoprotein is lacking; (b) the other major membrane-penetrating glycoprotein (band 3) has an altered electrophoretic mobility. 4. The apparent clinical normality of En(a-) cells suggests that the change in band 3 may compensate for the loss of the membrane sialoglycoproteins. It is clear that a viable erythrocyte can exist despite the absence of one of its major surface components.