Remote ischemic preconditioning prevents reduction in brachial artery flow-mediated dilation after strenuous exercise
Remote ischemic preconditioning prevents reduction in brachial artery flow-mediated dilation after strenuous exercise
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DOI：
10.1152/ajpheart.00272.2012
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发表时间：
2012-09-01
影响因子：
4.8
通讯作者：
Thijssen, Dick H. J.
中科院分区：
文献类型：
--
作者：
Bailey, Tom G.;Birk, Gurpreet K.;Thijssen, Dick H. J.
贝利TG，比尔克GK，电缆NT，阿特金森G，绿色DJ，琼斯H，蒂森DH。远程缺血预处理可防止剧烈运动后肱动脉血流介导的舒张功能降低。Am J Physiol Heart Circ Physiol 303：H533-H538，2012.首次发表于2012年6月22日; doi：10.1152/ajpheart.00272.2012.-剧烈运动与内皮功能的立即下降有关。反复缺血再灌注，称为远程缺血预处理（RIPC），能够保护缺血区域以外的血管内皮免受缺血诱导的损伤。我们研究了RIPC预防健康男性剧烈运动后内皮功能下降的假设。在一项随机交叉研究中，13名健康男性在下肢RIPC（4 X 5分钟220 mmHg双侧闭塞）或假干预（假手术; 4 X 5分钟20 mmHg双侧闭塞）之前进行跑步锻炼。参与者进行分级最大跑步机跑步测试，然后进行5公里计时试验（TT）。在RIPC或假手术前后以及5公里TT后检查肱动脉内皮功能。我们使用高分辨率超声多普勒测量了血流介导的血管舒张功能（FMD），这是内皮依赖性功能的一个指标。我们还计算了剪切率曲线下面积（从套囊放气到峰值扩张; SRAUC）。数据描述为平均值和95%置信区间。FMD变化0.30）。在假试验中，FMD在5 km TT后从5.1（4.4- 5.9）变为3.7%（2.6-4.8）（P = 0.02）。在RIPC试验中，FMD从IPC后的5.4（4.4-6.4）和5 km TT后的5.7%（4.6-6.8）变化可忽略不计（P = 0.60）。基线直径、SRAUC和达峰时间直径在5 km TT后均增加（P < 0.05），但这些变化不影响IPC介导的FMD维持。总之，这些数据表明，剧烈的下肢运动导致肱动脉FMD的急性下降，与健康男性的1.4%相似。然而，我们第一次发现，先前的下肢RIPC可将运动后肱动脉内皮依赖性功能维持在运动前水平。
Bailey TG, Birk GK, Cable NT, Atkinson G, Green DJ, Jones H, Thijssen DH. Remote ischemic preconditioning prevents reduction in brachial artery flow-mediated dilation after strenuous exercise. Am J Physiol Heart Circ Physiol 303: H533-H538, 2012. First published June 22, 2012; doi:10.1152/ajpheart.00272.2012.-Strenuous exercise is associated with an immediate decrease in endothelial function. Repeated bouts of ischemia followed by reperfusion, known as remote ischemic preconditioning (RIPC), is able to protect the endothelium against ischemia-induced injury beyond the ischemic area. We examined the hypothesis that RIPC prevents the decrease in endothelial function observed after strenuous exercise in healthy men. In a randomized, crossover study, 13 healthy men performed running exercise preceded by RIPC of the lower limbs (4 X 5-min 220-mmHg bilateral occlusion) or a sham intervention (sham; 4 X 5-min 20-mmHg bilateral occlusion). Participants performed a graded maximal treadmill running test, followed by a 5-km time trial (TT). Brachial artery endothelial function was examined before and after RIPC or sham, as well as after the 5-km TT. We measured flow-mediated dilation (FMD), an index of endothelium-dependent function, using high-resolution echo-Doppler. We also calculated the shear rate area-under-the-curve (from cuff deflation to peak dilatation; SRAUC). Data are described as mean and 95% confidence intervals. FMD changed by 0.30). In the sham trial, FMD changed from 5.1 (4.4- 5.9) to 3.7% (2.6-4.8) following the 5-km TT (P = 0.02). In the RIPC trial, FMD changed negligibly from 5.4 (4.4-6.4) post-IPC and 5.7% (4.6-6.8) post 5-km TT (P = 0.60). Baseline diameter, SRAUC, and time-to-peak diameter were all increased following the 5-km TT (P < 0.05), but these changes did not influence the IPC-mediated maintenance of FMD. In conclusion, these data indicate that strenuous lower-limb exercise results in an acute decrease in brachial artery FMD of similar to 1.4% in healthy men. However, we have shown for the first time that prior RIPC of the lower limbs maintains postexercise brachial artery endothelium-dependent function at preexercise levels.