Effect of chemotherapy and longitudinal analysis of circulating extracellular vesicle tissue factor activity in patients with pancreatic and colorectal cancer
Effect of chemotherapy and longitudinal analysis of circulating extracellular vesicle tissue factor activity in patients with pancreatic and colorectal cancer
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DOI：
10.1002/rth2.12317
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发表时间：
2020-03-09
影响因子：
4.6
通讯作者：
Mackman, Nigel
中科院分区：
文献类型：
--
作者：
Kasthuri, Raj S.;Hisada, Yohei;Mackman, Nigel
我们对胰腺癌和结直肠癌患者进行了一项纵向研究。我们测定了化疗对细胞外囊泡组织因子（EVTF）活性的影响，以及血浆EVTF活性与静脉血栓栓塞（VTE）和生存的关系。材料与方法本研究纳入13例胰腺癌患者和22例结直肠癌患者。在85天的研究期间收集血浆样本。研究结束后随访3个月。我们在研究期间（3个月）记录有症状的静脉血栓形成或在第85天通过超声检测无症状的深静脉血栓形成。我们测量了化疗前后EVTF的活性。结果与结论胰腺癌组有2例患者EVTF活性升高。其中一名患者出现症状性静脉血栓栓塞并死亡，另一名患者没有静脉血栓栓塞但死亡。化疗降低了2例高水平胰腺患者EVTF活性。结直肠癌组有4例患者发生静脉血栓栓塞，但EVTF活性未升高，无患者死亡。我们观察到EVTF活性与d -二聚体在胰腺癌而非结直肠癌患者中存在显著的临界相关性。在这项小型描述性研究中，2例胰腺癌患者EVTF活性水平升高。两名患者在研究期间死亡，其中一名患有静脉血栓栓塞。化疗降低了这些患者的EVTF活性。相比之下，在伴有或不伴有静脉血栓栓塞的结直肠癌患者中未观察到EVTF活性水平升高。
Introduction We conducted a longitudinal study in patients with pancreatic and colorectal cancer. We determined the effect of chemotherapy on extracellular vesicle tissue factor (EVTF) activity and the association of plasma EVTF activity with venous thromboembolism (VTE) and survival. Material and Methods We enrolled 13 patients with pancreatic and 22 patients with colorectal cancer. Plasma samples were collected during the 85-day study period. Patients were followed for 3 months after the study period. We recorded symptomatic VTE during the study period (3 months) or asymptomatic deep vein thrombosis detected by ultrasound at day 85. We measured EVTF activity before and after chemotherapy. Results and Conclusions In the pancreatic cancer group, 2 patients had elevated levels of EVTF activity. One of these patients developed symptomatic VTE and died, and the second patient did not have a VTE but died. Chemotherapy decreased EVTF activity in 2 pancreatic patients with high levels. In the colorectal cancer group, 4 patients developed VTE, but EVTF activity was not elevated in any patient and no patient died. We observed a borderline significant correlation between EVTF activity and D-dimer in the patients with pancreatic but not colorectal cancer. In this small descriptive study, 2 patients with pancreatic cancer had an elevated level of EVTF activity. Both patients died during the study period, and one had a VTE. Chemotherapy decreased EVTF activity in these patients. In contrast, elevated levels of EVTF activity were not observed in patients with colorectal cancer with or without VTE.